Evidence map›Paper›PMID 39567829›Full record

ArticleThe EMBO journal2024

Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration.

Jiajia Chen, Yucong Li, Yan Wang, Hui Wang, Jiaqi Yang, Xue Pan, Yun Zhao, Hao Xu, Penglei Jiang, Pengxu Qian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiajia ChenSchool of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0003-3846-5535
Yucong LiWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0009-0000-0118-6490
Yan WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangzhou, China.
Hui WangCenter for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jiaqi YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangzhou, China.
Xue PanSchool of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yun ZhaoWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Hao XuSchool of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Penglei JiangCenter for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Pengxu QianCenter for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID http://orcid.org/0000-0001-5636-6704
Hongwei WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangzhou, China.ORCID http://orcid.org/0000-0003-3581-8892
Zhi XieState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangzhou, China.
Kai LeiWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. leikai@westlake.edu.cn.ORCID http://orcid.org/0000-0003-0601-7391

Funding

MOST | National Natural Science Foundation of China (NSFC) 31970750MOST | National Natural Science Foundation of China (NSFC) 32122032MOST | National Natural Science Foundation of China (NSFC) 32470878
6 · The paper itself

Abstract

Tissue homeostasis and regeneration involve complex cellular changes. The role of rRNA modification-dependent translational regulation in these processes remains largely unknown. Planarians, renowned for their ability to undergo remarkable tissue regeneration, provide an ideal model for the analysis of differential rRNA regulation in diverse cell types during tissue homeostasis and regeneration. We investigated the role of RNA 2'-O-methyltransferase, Fibrillarin (FBL), in the planarian Schmidtea mediterranea and identified two FBL homologs: Smed-fbl-1 (fbl-1) and Smed-fbl-2 (fbl-2). Both are essential for planarian regeneration, but play distinct roles: fbl-1 is crucial for progenitor cell differentiation, while fbl-2 is important for late-stage epidermal lineage specification. Different 2'-O-methylation patterns were observed upon fbl-1 and fbl-2 knockdown, suggesting their roles in translation of specific mRNA pools during regeneration. Ribo-seq analysis further revealed differing impacts of fbl-1 and fbl-2 knockdown on gene translation. These findings indicate divergent roles of the duplicate fbl genes in specific cell lineage development in planarians and suggest a role of rRNA modifications in translational regulation during tissue maintenance and regeneration.

Indexed as

Cell LineageChromosomal Proteins, Non-HistoneHomeostasisPlanariansRegenerationAnimalsCell DifferentiationHelminth ProteinsProtein BiosynthesisRNA, RibosomalChromosomal Proteins, Non-HistonefibrillarinHelminth ProteinsRNA, RibosomalCell DifferentiationDuplicated FibrillarinEpidermal LineagePlanarianrRNA Modification

Identifiers

PMID39567829
PMCPMC11649923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.