Evidence map›Paper›PMID 39567792›Full record

ArticleNature2024

An integrated transcriptomic cell atlas of human neural organoids.

Zhisong He, Leander Dony, Jonas Simon Fleck, Artur Szałata, Katelyn X Li, Irena Slišković, Hsiu-Chuan Lin, Malgorzata Santel, Alexander Atamian, Giorgia Quadrato and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Dysregulated mScience advances · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. From a developmental atlas to maps of disease origin.Clinical and translational medicine · 2026
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zhisong He *Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland. zhisong.he@bsse.ethz.ch.ORCID 0000-0002-1502-4801
Leander Dony *Institute of Computational Biology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.ORCID 0000-0001-5697-6991
Jonas Simon Fleck *Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Artur SzałataInstitute of Computational Biology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.ORCID 0000-0001-8413-234X
Katelyn X LiInstitute of Computational Biology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.
Irena SliškovićInstitute of Computational Biology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.
Hsiu-Chuan LinDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Malgorzata SantelDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0009-0006-4947-8509
Alexander AtamianDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Giorgia QuadratoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-0717-4874
Jieran SunDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Sergiu P PașcaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3216-3248
Human Cell Atlas Organoid Biological Network
J Gray CampInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland. jarrettgrayson.camp@unibas.ch.ORCID 0000-0003-3295-1225
Fabian J TheisInstitute of Computational Biology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany. fabian.theis@helmholtz-munich.de.ORCID 0000-0002-2419-1943
Barbara TreutleinDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland. barbara.treutlein@bsse.ethz.ch.ORCID 0000-0002-3299-5597

Funding

Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
NICHD NIH HHS T32 HD060549
6 · The paper itself

Abstract

Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to study human brain development, evolution and disease. However, it is unclear which parts of the human brain are covered by existing protocols, and it has been difficult to quantitatively assess organoid variation and fidelity. Here we integrate 36 single-cell transcriptomic datasets spanning 26 protocols into one integrated human neural organoid cell atlas totalling more than 1.7 million cells

Indexed as

Gene Expression ProfilingNeuronsOrganoidsSingle-Cell AnalysisTranscriptomeAtlases as TopicBrainCohort StudiesData CurationDatasets as TopicHumansModels, NeurologicalNervous System DiseasesPluripotent Stem CellsUser-Computer Interface

Identifiers

PMID39567792
PMCPMC11578878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.