Evidence map›Paper›PMID 39567770›Full record

ArticleNature cardiovascular research2024

Intrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model.

Emily E Bramel, Wendy A Espinoza Camejo, Tyler J Creamer, Leda Restrepo, Muzna Saqib, Rustam Bagirzadeh, Anthony Zeng, Jacob T Mitchell, Genevieve L Stein-O'Brien, Albert J Pedroza and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Transforming growth factor-beta (TGF-β) in the pathogenesis of hereditary thoracic aneurysm disorders.Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Emily E BramelMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4602-9506
Wendy A Espinoza CamejoMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tyler J CreamerMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Leda RestrepoMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1784-3752
Muzna SaqibMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rustam BagirzadehMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anthony ZengMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0009-0008-2244-7256
Jacob T MitchellMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5370-9692
Genevieve L Stein-O'BrienMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Albert J PedrozaDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5291-5980
Michael P FischbeinDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Harry C DietzMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6856-0165
Elena Gallo MacFarlaneMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. egallo1@jhmi.edu.ORCID http://orcid.org/0000-0001-5677-6842

Funding

MECHANISTIC BASIS FOR REGIONAL PREDISPOSITION FOR ANEURYSMR01HL147947 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GALLO MACFARLANE, ELENA · 2019 to 2023
$3.2M
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
GATA4 as a Modulator of Aortic Root Sensitivity to Mechanochemical Disruptions Caused by an Aneurysm-causing MutationF31HL163924 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BRAMEL, EMILY ELOISE · 2022 to 2023
$78k
NHLBI NIH HHS F31 HL163924NHLBI NIH HHS R01 HL147947NIH HHS S10 OD023548U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL163924U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL147947
6 · The paper itself

Abstract

Loeys-Dietz syndrome (LDS) is a connective tissue disorder caused by mutations that decrease transforming growth factor-β signaling. LDS-causing mutations increase the risk of aneurysm throughout the arterial tree, yet the aortic root is a site of heightened susceptibility. Here we investigate the heterogeneity of vascular smooth muscle cells (VSMCs) in the aorta of Tgfbr1

Indexed as

Disease Models, AnimalGATA4 Transcription FactorLoeys-Dietz SyndromeMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptor, Transforming Growth Factor-beta Type IAnimalsAortaAortic AneurysmDilatation, PathologicHumansMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionGATA4 protein, humanGata4 protein, mouseGATA4 Transcription FactorReceptor, Transforming Growth Factor-beta Type ITGFBR1 protein, humanTgfbr1 protein, mouse

Identifiers

PMID39567770
PMCPMC11634776

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.