Evidence map›Paper›PMID 39567762›Full record

ArticleNature immunology2024

Remodeling of Il4-Il13-Il5 locus underlies selective gene expression.

Hiroyuki Nagashima, Justin Shayne, Kan Jiang, Franziska Petermann, Aleksandra Pękowska, Yuka Kanno, John J O'Shea

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Immunotherapy for asthma.Cellular & molecular immunology · 2025
    Review
  7. Article
  8. The immunology of asthma.Nature immunology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroyuki NagashimaLymphocyte Cell Biology Section, NIAMS, NIH, Bethesda, MD, USA. hiroyuki.nagashima@nih.gov.ORCID http://orcid.org/0000-0001-8405-6746
Justin ShayneLymphocyte Cell Biology Section, NIAMS, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0009-0003-5617-6494
Kan JiangBiodata Mining and Discovery Section, NIAMS, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9065-4574
Franziska PetermannLymphocyte Cell Biology Section, NIAMS, NIH, Bethesda, MD, USA.
Aleksandra PękowskaGenomics and Immunity Section, NIAMS, NIH, Bethesda, MD, USA.
Yuka KannoLymphocyte Cell Biology Section, NIAMS, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5668-9319
John J O'SheaLymphocyte Cell Biology Section, NIAMS, NIH, Bethesda, MD, USA. john.oshea@nih.gov.ORCID http://orcid.org/0000-0002-6456-9752

Funding

Stat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3M
Intramural NIH HHS ZIA AR041159
6 · The paper itself

Abstract

The type 2 cytokines, interleukin (IL)-4, IL-13 and IL-5 reside within a multigene cluster. Both innate (ILC2) and adaptive T helper 2 (T

Indexed as

Gene Expression RegulationInterleukin-13Interleukin-4AnimalsInterleukin-5MiceMice, Inbred C57BLMice, KnockoutMultigene FamilyTh2 CellsInterleukin-13Interleukin-4Interleukin-5

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.