Evidence map›Paper›PMID 39567721›Full record

ArticleScientific reports2024

Oxidative damage and mitochondrial dysfunction in cystathionine beta-synthase deficiency.

Mehmet Cihan Balci, Asuman Gedikbasi, Sukru Anil Dogan, Sevde Kahraman, Suzin Tatoryan, Sebnem Tekin Neijmann, Meryem Karaca, Fatmahan Atalar, Gulden Gokcay

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mehmet Cihan BalciDivision of Pediatric Nutrition and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey. mehmetcbalci@hotmail.com.
Asuman GedikbasiDepartment of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Türkiye, Turkey.
Sukru Anil DoganDepartment of Molecular Biology and Genetics, Center for Life Sciences and Technologies, Bogazici University, Istanbul, Türkiye, Turkey.
Sevde KahramanDepartment of Rare Diseases, Institute of Health Sciences, Istanbul University, Istanbul, Türkiye, Turkey.
Suzin TatoryanDepartment of Rare Diseases, Institute of Child Health, Istanbul University, Istanbul, Türkiye, Turkey.
Sebnem Tekin NeijmannDepartment of Rare Diseases, Institute of Health Sciences, Istanbul University, Istanbul, Türkiye, Turkey.
Meryem KaracaDivision of Pediatric Nutrition and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey.
Fatmahan AtalarDepartment of Rare Diseases, Institute of Child Health, Istanbul University, Istanbul, Türkiye, Turkey.
Gulden GokcayDivision of Pediatric Nutrition and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey.

Funding

Istanbul University Scientific Research Projects Unit TSA-2022-39178
6 · The paper itself

Abstract

Cystathionine beta-synthase deficiency (CBSD) is the most prevalent inherited disorder of homocysteine metabolism in the transsulphuration pathway. Research have suggested oxidative stress and inflammation as candidate pathogenic mechanisms in CBSD. This study aims to evaluate mitochondrial dysfunction and oxidative stress biomarkers in cystathionine beta-synthase deficiency (CBSD) patients, which may aid in understanding the pathogenesis of CBSD and improving treatment. The study group comprised 23 patients with a diagnosis of CBSD and healthy controls. We analysed serum levels of NAD

Indexed as

Fibroblast Growth FactorsGrowth Differentiation Factor 15HomocysteineHomocystinuriaMitochondriaOxidative StressAdolescentAdultBiomarkersCase-Control StudiesChildChild, PreschoolCystathionine beta-SynthaseFemaleHumansMaleBiomarkersCystathionine beta-SynthaseFibroblast Growth FactorsGDF15 protein, humanGrowth Differentiation Factor 15HomocysteineNADCystathionine beta synthase deficiencyFibroblast growth factor 21Growth differentiation factor 15MitochondriaOxidative stress

Identifiers

PMID39567721
PMCPMC11579338

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.