ArticleEye (London, England)2025
Intravitreal Faricimab in treatment-naïve neovascular age-related macular degeneration: real-world outcome of 12-week extension after the loading dose from a UK centre.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME.Journal of clinical medicine · 2026Review
- Real-Life 1-Year Results and Predictors of Visual Outcome with Intravitreal Faricimab for Treatment of Exudative Neovascular Age-Related Macular Degeneration.Ophthalmology and therapy · 2026Article
- Faricimab in Treatment-Naïve nAMD: Regional UK Real-World Experience.Advances in therapy · 2026Article
- Efficacy and safety of intravitreal faricimab for choroidal neovascularization secondary to central serous chorioretinopathy - a multicentre study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Visual Gains with Faricimab vs Aflibercept 8 mg in Naïve Retinovascular Disease: Global Real-World Cases and Literature Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the visual outcome of extension to 12-weekly intervals (Q12W) following 4 loading doses of intravitreal Faricimab injections as described in the TENAYA and LUCERENE trials for the management of treatment-naïve neovascular Age-related Macular Degeneration (nAMD).
methodsA retrospective analysis was carried out on all treatment-naïve nAMD patients who started Faricimab intravitreal injections in the period between 1
resultsSixty-eight eyes completed the one-year of treatment. The mean (SD) age was 79.9 (8.7) years and 61.8% were females. The mean (SD) number of injections at 52 weeks was 6.8 (0.8). The BCVA improved from baseline by a mean (SD) of 7.0 (10.8) letters at 12 weeks (p < 0.001), 7.3 (12.1) letters at 24 weeks (p < 0.001) and 8.2 (13.4) letters at 52 weeks (p < 0.001). The mean (SD) reduction in CST was 114.8 (SD 122.8) microns at 24 weeks (p < 0.001), and 89.4 (121.9) microns at 52 weeks (p < 0.001).
conclusionA Q12W approach following 4 loading doses of Faricimab for the treatment of nAMD in real-world achieves excellent visual outcomes comparable to pivotal trial with optimum number of injections in the first year.
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