Evidence map›Paper›PMID 39567690›Full record

ArticleNature2025

A functional microbiome catalogue crowdsourced from North American rivers.

Mikayla A Borton, Bridget B McGivern, Kathryn R Willi, Ben J Woodcroft, Annika C Mosier, Derick M Singleton, Ted Bambakidis, Aaron Pelly, Rebecca A Daly, Filipe Liu and 20 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  13. Microbial Community Succession Sustains Fish Diversity in the Upper Yangtze River Reserve.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Mikayla A BortonDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA. mborton@colostate.edu.ORCID 0000-0001-8037-4253
Bridget B McGivernDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0001-9023-0018
Kathryn R WilliDepartment of Ecosystem Science and Sustainability, Colorado State University, Fort Collins, CO, USA.
Ben J WoodcroftCentre for Microbiome Research, School of Biomedical Sciences, Queensland University of Technology, Translational Research Institute, Woolloongabba, Queensland, Australia.ORCID 0000-0003-0670-7480
Annika C MosierDepartment of Integrative Biology, University of Colorado Denver, Denver, CO, USA.ORCID 0000-0001-5333-4854
Derick M SingletonDepartment of Integrative Biology, University of Colorado Denver, Denver, CO, USA.
Ted BambakidisDepartment of Microbiology, Oregon State University, Corvallis, OR, USA.ORCID 0000-0001-8452-3500
Aaron PellyEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.
Rebecca A DalyDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.
Filipe LiuData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.
Andrew FreiburgerData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.
Janaka N EdirisingheData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.
José P FariaData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.ORCID 0000-0001-9302-7250
Robert DanczakEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.
Ikaia LeleiwiDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.
Amy E GoldmanEnergy and Environment Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0003-0490-6451
Michael J WilkinsDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-3595-0853
Ed K HallDepartment of Ecosystem Science and Sustainability, Colorado State University, Fort Collins, CO, USA.
Christa PennacchioDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-0297-3960
Simon RouxDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Emiley A Eloe-FadroshDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-8162-1276
Stephen P GoodDepartment of Biological & Ecological Engineering, Oregon State University, Corvallis, OR, USA.ORCID 0000-0003-4363-1577
Matthew B SullivanDepartment of Microbiology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-8398-8234
Elisha M Wood-CharlsonEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Christopher S MillerDepartment of Integrative Biology, University of Colorado Denver, Denver, CO, USA.ORCID 0000-0002-9448-8144
Matthew R V RossDepartment of Ecosystem Science and Sustainability, Colorado State University, Fort Collins, CO, USA.
Christopher S HenryData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.
Byron C CrumpCollege of Earth, Ocean and Atmospheric Sciences, Oregon State University, Corvallis, OR, USA.ORCID 0000-0001-7062-1273
James C StegenEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0001-9135-7424
Kelly C WrightonDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA. wrighton@colostate.edu.ORCID 0000-0003-0434-4217

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Environmental System Science (ESS) ProgramNCI NIH HHS P30 CA046934US Department of Energy (DOE) Office of Science, Office of Biological and Environmental ResearchUS DOE, Office of Science, Office of Biological and Environmental ResearchUS National Science Foundation
6 · The paper itself

Abstract

Predicting elemental cycles and maintaining water quality under increasing anthropogenic influence requires knowledge of the spatial drivers of river microbiomes. However, understanding of the core microbial processes governing river biogeochemistry is hindered by a lack of genome-resolved functional insights and sampling across multiple rivers. Here we used a community science effort to accelerate the sampling, sequencing and genome-resolved analyses of river microbiomes to create the Genome Resolved Open Watersheds database (GROWdb). GROWdb profiles the identity, distribution, function and expression of microbial genomes across river surface waters covering 90% of United States watersheds. Specifically, GROWdb encompasses microbial lineages from 27 phyla, including novel members from 10 families and 128 genera, and defines the core river microbiome at the genome level. GROWdb analyses coupled to extensive geospatial information reveals local and regional drivers of microbial community structuring, while also presenting foundational hypotheses about ecosystem function. Building on the previously conceived River Continuum Concept

Indexed as

CrowdsourcingMicrobiotaRiversCarbon CycleDatabases, FactualMetagenomeTranscriptomeUnited StatesWater Microbiology

Identifiers

PMID39567690
PMCPMC11666465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.