Evidence map›Paper›PMID 39567687›Full record

ArticleNature2024

Normal breast tissues harbour rare populations of aneuploid epithelial cells.

Yiyun Lin, Junke Wang, Kaile Wang, Shanshan Bai, Aatish Thennavan, Runmin Wei, Yun Yan, Jianzhuo Li, Heba Elgamal, Emi Sei and 11 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yiyun Lin *Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-9277-3048
Junke Wang *Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kaile WangDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-2249-1026
Shanshan BaiDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Aatish ThennavanDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Runmin WeiDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yun YanDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-3701-9608
Jianzhuo LiDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Heba ElgamalDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Emi SeiDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Anna CasasentDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mitchell RaoDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chenling TangDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Asha S MultaniDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jin MaDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jessica MontalvanDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.
Chandandeep NagiDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Sebastian WinocourDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.
Bora LimDepartment of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4182-6058
Alastair ThompsonDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.
Nicholas NavinDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. nnavin@mdanderson.org.ORCID 0000-0002-2106-8624

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
DELINEATING THE EVOLUTION AND ECOLOGY OF CHEMORESISTANCE IN BREAST CANCER WITH SINGLE CELL GENOMICSR01CA236864 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAVIN, NICHOLAS · 2020 to 2024
$2.3M
INVESTIGATING TUMOR INITIATION AND INVASION IN PREMALIGNANT BREAST CANCER WITH SPATIAL SINGLE CELL GENOMICSR01CA240526 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAVIN, NICHOLAS · 2019 to 2023
$1.8M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA236864NCI NIH HHS R01 CA240526
6 · The paper itself

Abstract

Aneuploid epithelial cells are common in breast cancer

Indexed as

AneuploidyBreastCell LineageDNA Copy Number VariationsEpithelial CellsAdultAge FactorsBreast NeoplasmsCells, CulturedChromatinClone CellsFemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansMiddle AgedChromatin

Identifiers

PMID39567687
PMCPMC12367288

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.