Evidence map›Paper›PMID 39567682›Full record

ArticleNature2024

Cephalopod-inspired jetting devices for gastrointestinal drug delivery.

G Arrick, D Sticker, A Ghazal, Y Lu, T Duncombe, D Gwynne, B Mouridsen, J Wainer, J P H Jepsen, T S Last and 32 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Liquid Metals for Reconfigurable Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Physical Intelligence in Small-Scale Robots and Machines.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. A Pill That Prints-An Ingestible Bioprinter for Non-Invasive Structured Bioink Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Stable magnetic soft structures.Science advances · 2025
    Article
  17. Article
  18. Article
  19. Autonomous devices for drug delivery.Nature biomedical engineering · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

G Arrick *Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
D Sticker *Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
A Ghazal *Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
Y LuDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
T DuncombeGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
D GwynneDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
B MouridsenGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
J WainerDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-4845-228X
J P H JepsenGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
T S LastDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
D SchultzGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
K HessDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-2837-0305
E Medina De AlbaGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.ORCID 0009-0005-6579-6307
S MinDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-7308-6840
M PoulsenGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
C AnkerGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
P KarandikarDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-3529-2037
H D PedersenGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
J CollinsDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
N E EgeciogluGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
S TamangDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
C ClevelandGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
K IshidaDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
A H UhrenfeldtGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
J KuosmanenDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
M PereverzinaGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
A HaywardDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
R K KirkGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
S YouDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
C M DalsgaardGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
S B GunnarssonGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
I PatsiGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
A BohrGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
A AzzarelloGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
M R FrederiksenGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
P HerskindGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
J LiDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
N RoxhedMicro and Nanosystems, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-7147-6730
U L RahbekGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.ORCID 0000-0002-1255-0232
J J WaterGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark.
S T BuckleyGlobal Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark. spby@novonordisk.com.
G TraversoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.ORCID 0000-0001-7851-4077

Funding

Natural Sciences and Engineering Research Council of CanadaNovo Nordisk A/S
6 · The paper itself

Abstract

Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the body, including the gastrointestinal tract

Indexed as

Drug Delivery SystemsEquipment DesignGastrointestinal TractInjections, JetAnimalsCephalopodaDogsFemaleGlucagon-Like Peptide 1InsulinMalePressureRNA, Small InterferingSwineGlucagon-Like Peptide 1InsulinRNA, Small Interfering

Identifiers

PMID39567682
PMCPMC11634773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.