Evidence map›Paper›PMID 39567681›Full record

ReviewNature reviews. Urology2025

Metastasis development in non-muscle-invasive bladder cancer.

Michael Leyderman, Thenappan Chandrasekar, Petros Grivas, Roger Li, Seetharam Bhat, Alina Basnet, Oleg Shapiro, Joseph Jacob, Michael A Daneshvar, Eyal Kord and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael LeydermanDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Thenappan ChandrasekarDepartment of Urology, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0002-2173-5028
Petros GrivasDepartment of Medicine, Division of Medical Oncology, University of Washington School of Medicine, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Roger LiDepartment of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID 0000-0003-1274-7200
Seetharam BhatDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Alina BasnetDepartment of Medical Oncology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-0062-9007
Oleg ShapiroDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Joseph JacobDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Michael A DaneshvarDepartment of Urology, University of California, Irvine, CA, USA.
Eyal KordDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Gennady BratslavskyDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-2712-4375
Hanan GoldbergDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA. Gohanan@gmail.com.ORCID 0000-0002-5777-2138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-muscle-invasive bladder cancer (NMIBC) is the most common type of bladder cancer presentation and is characterized by a varying probability of recurrence and progression. Sporadically, patients with NMIBC might also develop tumour metastases without any pathological evidence of muscle-invasive disease within the bladder, a condition known as metastatic NMIBC. In the published literature, this phenomenon is limited to several case reports and small reviews, with few data regarding the possible aetiologies. Several possible factors can be potentially associated with metastatic NMIBC, including tumour understaging, the number of transurethral resection procedures received by the patient, the presence of circulating tumour cells, the modality used for diagnostic cystoscopy and possible gender-associated differences. In this Perspective, our aim was to integrate and report currently available data on this relatively rare entity and provide some potential aetiological explanations.

Indexed as

Urinary Bladder NeoplasmsHumansNeoplasm InvasivenessNeoplasm MetastasisNon-Muscle Invasive Bladder Neoplasms

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.