Evidence map›Paper›PMID 39567670›Full record

ArticleScientific reports2024

Prognostic significance of CD8 and TCF1 double positive T cell subset in microsatellite unstable gastric cancer.

Juhyeong Park, Soo Kyung Nam, Yoonjin Kwak, Hyeon Jeong Oh, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang, Hye Seung Lee

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juhyeong ParkSeoul National University College of Medicine, Seoul, Korea.
Soo Kyung NamDepartment of Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul, Korea.
Yoonjin KwakDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Hyeon Jeong OhDepartment of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
Seong-Ho KongDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Do Joong ParkDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Hyuk-Joon LeeDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Han-Kwang YangDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Hye Seung LeeDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. hye2@snu.ac.kr.

Funding

Korea government (Ministry of Science and ICT) RS-2024-00337984
6 · The paper itself

Abstract

Microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits high tumor-infiltrating lymphocyte (TIL) density. Despite the recognized significance of the immune microenvironment in MSI-H GC, our understanding of TIL remains limited. This study aimed to investigate the clinicopathologic and prognostic implications of T cell subsets in MSI-H GC. Single immunohistochemistry (IHC) for CD8, TCF1, and CD103, and double IHC for CD8/TCF1 and CD8/CD103 were performed in 382 surgically resected MSI-H GC samples. Densities of single or double positive immune cells were quantified and correlated with clinicopathologic features and overall survival (OS). TCF1 + cell densities showed weak correlations with CD8 + and CD103 + cell densities, while CD8+/TCF1 + cell density moderately correlated with CD8+/CD103 + cell density (R

Indexed as

CD8-Positive T-LymphocytesHepatocyte Nuclear Factor 1-alphaLymphocytes, Tumor-InfiltratingMicrosatellite InstabilityStomach NeoplasmsAdultAgedAged, 80 and overAntigens, CDFemaleHumansImmunohistochemistryIntegrin alpha ChainsMaleMiddle AgedPrognosisalpha E integrinsAntigens, CDHepatocyte Nuclear Factor 1-alphaHNF1A protein, humanIntegrin alpha ChainsAlpha E integrinsMicrosatellite instabilityStomach neoplasmsT cell transcription factor 1Tumor-Infiltrating Lymphocytes

Identifiers

PMID39567670
PMCPMC11579470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.