Evidence map›Paper›PMID 39567624›Full record

ArticleScientific reports2024

Microfluidics chips fabrication techniques comparison.

Xiaocheng Liu, Antao Sun, Jan Brodský, Imrich Gablech, Tomáš Lednický, Petra Vopařilová, Ondřej Zítka, Wen Zeng, Pavel Neužil

Abstract readComparative Study
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  12. Recent Advancements in the SERS-Based Detection ofSensors (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaocheng LiuMinistry of Education Key Laboratory of Micro and Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, People's Republic of China.
Antao SunMinistry of Education Key Laboratory of Micro and Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, People's Republic of China.
Jan BrodskýDepartment of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Technická 3058/10, Brno, 616 00, Czech Republic.
Imrich GablechDepartment of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Technická 3058/10, Brno, 616 00, Czech Republic. imrich.gablech@vutbr.cz.
Tomáš LednickýDepartment of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Technická 3058/10, Brno, 616 00, Czech Republic.
Petra VopařilováDepartment of Chemistry and Biochemistry, Mendel University in Brno, Zemědělská 1, Brno, 613 00, Czech Republic.
Ondřej ZítkaDepartment of Chemistry and Biochemistry, Mendel University in Brno, Zemědělská 1, Brno, 613 00, Czech Republic.
Wen ZengMinistry of Education Key Laboratory of Micro and Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, People's Republic of China. zengwen@nwpu.edu.cn.
Pavel NeužilMinistry of Education Key Laboratory of Micro and Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, People's Republic of China. pavel.neuzil@nwpu.edu.cn.

Funding

European Regional Development Fund CZ.02.1.01/0.0/0.0/16_025/0007314National Natural Science Foundation of China 52150710541Natural Science Foundation of Shaanxi Province 2023-JC-YB-306
6 · The paper itself

Abstract

This study investigates various microfluidic chip fabrication techniques, highlighting their applicability and limitations in the context of urgent diagnostic needs showcased by the COVID-19 pandemic. Through a detailed examination of methods such as computer numerical control milling of a polymethyl methacrylate, soft lithography for polydimethylsiloxane-based devices, xurography for glass-glass chips, and micromachining-based silicon-glass chips, we analyze each technique's strengths and trade-offs. Hence, we discuss the fabrication complexity and chip thermal properties, such as heating and cooling rates, which are essential features of chip utilization for a polymerase chain reaction. Our comparative analysis reveals critical insights into material challenges, design flexibility, and cost-efficiency, aiming to guide the development of robust and reliable microfluidic devices for healthcare and research. This work underscores the importance of selecting appropriate fabrication methods to optimize device functionality, durability, and production efficiency.

Indexed as

COVID-19Lab-On-A-Chip DevicesDimethylpolysiloxanesEquipment DesignHumansMicrofluidic Analytical TechniquesMicrofluidicsPolymethyl MethacrylateSARS-CoV-2DimethylpolysiloxanesPolymethyl Methacrylate

Identifiers

PMID39567624
PMCPMC11579384

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.