Evidence map›Paper›PMID 39567583›Full record

ArticleScientific reports2024

Transcriptomic analysis reveals a critical role for activating G

Thomas K Hiron, Joana Aguiar, Jonathan M Williams, Sara Falcone, Paul A Norman, Jonathan Elliott, Robert C Fowkes, Harriet M Syme, Lucy J Davison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. ATranslational pediatrics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas K HironDepartment of Clinical Science and Services, The Royal Veterinary College, Hertfordshire, AL9 7TA, UK.
Joana AguiarDepartment of Clinical Science and Services, The Royal Veterinary College, Hertfordshire, AL9 7TA, UK.
Jonathan M WilliamsDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, Hertfordshire, AL9 7TA, UK.
Sara FalconeDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Paul A NormanDepartment of Clinical Science and Services, The Royal Veterinary College, Hertfordshire, AL9 7TA, UK.
Jonathan ElliottDepartment of Comparative Biomedical Science, The Royal Veterinary College, London, NW1 0TU, UK.
Robert C FowkesDepartment of Comparative Biomedical Science, The Royal Veterinary College, London, NW1 0TU, UK.
Harriet M SymeDepartment of Clinical Science and Services, The Royal Veterinary College, Hertfordshire, AL9 7TA, UK.
Lucy J DavisonDepartment of Clinical Science and Services, The Royal Veterinary College, Hertfordshire, AL9 7TA, UK. ldavison@rvc.ac.uk.

Funding

Medical Research Council MR/R007977/1
6 · The paper itself

Abstract

Feline hyperthyroidism (FHT) is a debilitating disease affecting > 10% of elderly cats. It is generally characterised by chronic elevation of thyroid hormone in the absence of circulating TSH. Understanding of the molecular pathogenesis of FHT is currently limited. However, FHT shares clinical and histopathological similarities with human toxic multinodular goitre, which has been associated with activating mutations in TSH receptor (TSHR) and G

Indexed as

Cat DiseasesGTP-Binding Protein alpha Subunits, GsHyperthyroidismReceptors, ThyrotropinAnimalsCatsGene Expression ProfilingMutationMutation, MissenseSignal TransductionThyroid GlandTranscriptomeGTP-Binding Protein alpha Subunits, GsReceptors, Thyrotropin

Identifiers

PMID39567583
PMCPMC11579033

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.