Evidence map›Paper›PMID 39567568›Full record

ArticleScientific reports2024

pH-Dependent migratory behaviors of neutrophil-like cells in a microfluidic device with controllability of dissolved gas concentrations.

Masashi Tomita, Satomi Hirose, Taishi Nakamura, Kenichi Funamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Masashi TomitaGraduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-Aza Aoba, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan.
Satomi HiroseGraduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-Aza Aoba, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan.
Taishi NakamuraGraduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-Aza Aoba, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan.
Kenichi FunamotoGraduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-Aza Aoba, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan. funamoto@tohoku.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory microenvironments often become acidic (pH < 7.4) due to tissue oxygen deprivation and lactate release in glycolysis by activated immune cells. Although neutrophils are known to accumulate in such microenvironments, the effects of pH on their migration are not fully understood. Here, we first investigated the pH control around cultured cells with a microfluidic device, which was equipped with two gas channels above three parallel media channels. By supplying gas mixtures with predefined carbon dioxide (CO

Indexed as

Carbon DioxideCell MovementLab-On-A-Chip DevicesNeutrophilsHL-60 CellsHumansHydrogen-Ion ConcentrationCarbon DioxideDissolved gasMicroenvironmentMicrofluidic deviceNeutrophilpH

Identifiers

PMID39567568
PMCPMC11579455

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.