Evidence map›Paper›PMID 39567542›Full record

ArticleNPJ microgravity2024

Development and characterization of a low intensity vibrational system for microgravity studies.

Omor M Khan, Will Gasperini, Chess Necessary, Zach Jacobs, Sam Perry, Jason Rexroat, Kendall Nelson, Paul Gamble, Twyman Clements, Maximilien DeLeon and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Omor M KhanDepartment of Mechanical and Biomedical Engineering, Boise State University, Boise, ID, 83725, USA.ORCID http://orcid.org/0009-0006-0740-7462
Will GasperiniDepartment of Mechanical and Biomedical Engineering, Boise State University, Boise, ID, 83725, USA.
Chess NecessarySpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.ORCID http://orcid.org/0009-0006-4093-5275
Zach JacobsSpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.
Sam PerrySpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.
Jason RexroatSpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.
Kendall NelsonSpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.
Paul GambleSpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.
Twyman ClementsSpace Tango Inc, 611 Winchester, Lexington, KY, 40505, USA.
Maximilien DeLeonDepartment of Bioengineering, Rice University, Houston, TX, 77005, USA.
Sean HowardDepartment of Mechanical and Biomedical Engineering, Boise State University, Boise, ID, 83725, USA.ORCID http://orcid.org/0000-0001-7556-1951
Anamaria ZavalaDepartment of Mechanical and Biomedical Engineering, Boise State University, Boise, ID, 83725, USA.
Mary Farach-CarsonDepartment of Bioengineering, Rice University, Houston, TX, 77005, USA.
Elizabeth BlaberCenter for Biotechnology and Rd. Interdisciplinary Studies, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.ORCID http://orcid.org/0000-0002-1924-0587
Danielle WuDepartment of Bioengineering, Rice University, Houston, TX, 77005, USA.
Aykut SaticiDepartment of Mechanical and Biomedical Engineering, Boise State University, Boise, ID, 83725, USA. aykutsatici@boisestate.edu.
Gunes UzerDepartment of Mechanical and Biomedical Engineering, Boise State University, Boise, ID, 83725, USA. gunesuzer@boisestate.edu.ORCID http://orcid.org/0000-0002-1178-4942

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OCHOA-REPARAZ, JAVIER · 2014 to 2023
$22.7M
Optimizing Deep Brain Stimulation for Parkinson's Disease.P20GM148321 · NIGMS · BOISE STATE UNIVERSITY · PI Javier Ochoa-Reparaz · 2023 to 2026
$10.2M
Role of LINC-mediated Mechanosignaling in MSC AgingR01AG059923 · NIA · BOISE STATE UNIVERSITY · PI UZER, GUNES · 2020 to 2024
$1.6M
Live Cell Imaging System for Biomechanics and Mechanobiology ResearchS10OD032354 · OD · BOISE STATE UNIVERSITY · PI UZER, GUNES · 2022 to 2022
$233k
NIA NIH HHS R01 AG059923NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095NIGMS NIH HHS P20 GM148321NIH HHS S10 OD032354
6 · The paper itself

Abstract

Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor's design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.

Identifiers

PMID39567542
PMCPMC11579003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.