ArticleNPJ Parkinson's disease2024
Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI.
Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Low vs high frequency deep brain stimulation for Parkinson's disease-associated motor symptoms: A systematic review and meta-analysis of randomized control trials.Journal of Parkinson's disease · 2026Review
- Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.Cells · 2026Review
- Pollutants regulate changes in pathological markers of neurodegenerative diseases: a new perspective in environmental toxicology.Frontiers in toxicology · 2026Review
- Differential associations between tongue pressure and handgrip strength with MDS-UPDRS part III motor symptoms in Parkinson's disease.Frontiers in neurology · 2026Observational
- Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson's disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the "push-pull" effect of basal ganglia network. Specifically, increased GABAergic projection into the thalamus from basal ganglia worsens rigidity, while reduced GABAergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to "push" the network to an abnormal state. Conversely, DBS can alleviate rigidity by enhancing GABAergic projections within the basal ganglia, and improve bradykinesia by reducing cortical projections to basal ganglia, exhibiting that DBS "pulls" the network to a healthy state. This work combines the microscopic and macroscopic neural information for understanding PD and its treatment.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.