Evidence map›Paper›PMID 39567535›Full record

ArticleNature communications2024

Ordered assemblies of peptide nanoparticles with only positive charge.

Yi Shi, Tianren Zhang, Rui Guo, Zihan Zhang, Amanda L McCahill, Yao Tang, Sabrina E Liskey, Dai-Bei Yang, Christopher J Kloxin, Jeffery G Saven and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi Shi *Department of Materials Science and Engineering, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0000-0002-9084-8069
Tianren Zhang *Department of Materials Science and Engineering, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0000-0003-2899-5727
Rui Guo *Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Zihan ZhangDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0000-0002-5912-2497
Amanda L McCahillDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0000-0002-4943-2790
Yao TangDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA.
Sabrina E LiskeyDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA.
Dai-Bei YangDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Christopher J KloxinDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA.
Jeffery G SavenDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA. saven@sas.upenn.edu.ORCID http://orcid.org/0000-0001-5027-7241
Darrin J PochanDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA. pochan@udel.edu.ORCID http://orcid.org/0000-0002-0454-2339

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
A Simultaneous SAXS/WAXS Detector System for Solving Biological StructuresS10OD012331 · OD · STATE UNIVERSITY NEW YORK STONY BROOK · PI ALLAIRE, MARC · 2012 to 2012
$1.1M
NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM133893NIH HHS S10 OD012331U.S. Department of Energy (DOE) DE-SC0019282
6 · The paper itself

Abstract

Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil 'bundlemer' nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates. Similarly, porous lattices are formed in mixtures of SC/MC particles of opposite charges while MC/MC mixtures of opposite charges produce only amorphous aggregates. The lattice structure is inferred with a machine learning optimization approach. The differences between SC and MC particle behaviours directly show the importance of surface electrostatic patchiness.

Identifiers

PMID39567535
PMCPMC11579329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.