Evidence map›Paper›PMID 39567423›Full record

ReviewCell biochemistry and biophysics2025

Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths.

Raed Obaid Saleh, Hamad Ali Hamad, Maryam Abdulrahman Najim, Soumya V Menon, Mandeep Kaur, G V Sivaprasad, Mohammad Abohassan, Wen-Tau Juan, Beneen Husseen, Yasser Fakri Mustafa

RetractedAbstract readReviewRetracted Publication
PubMed Publisher
In one paragraph

Review in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Raed Obaid SalehMedical Laboratory Techniques Department, College of Health and Medical Technology, University of Al Maarif, Anbar, Iraq. Dr.raed.obaid@uoa.edu.iq.
Hamad Ali HamadDepartment of Pathological Analysis, Collage of Applied Sciences, University of Fallujah, Fallujah, Iraq.
Maryam Abdulrahman NajimDepartment of Biology, College Education for Pure Science, University of Anbar, Al-Anbar, Iraq.
Soumya V MenonDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Mandeep KaurDepartment of Sciences, Vivekananda Global University, Jaipur, Rajasthan, India.
G V SivaprasadDepartment of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India.
Mohammad AbohassanDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Wen-Tau JuanDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Beneen HusseenMedical Laboratory Technique college, The Islamic University, Najaf, Iraq.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.

Funding

King Khalid University R.G.P.2/315/44
6 · The paper itself

Abstract

Exosomes are extracellular vesicles with a diameter ranging from 40 to 160 nm. They are produced by hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs) and Kupffer cells in liver tissue. The secretion of exosomes might vary in quantity and composition in reaction to multiple triggers and various stages of disease. They transport various payloads, such as proteins, DNAs, and RNAs, and enable cell interaction to regulate myriad physiological and pathological processes in liver tissue. Long non-coding RNAs (lncRNAs) are a crucial component of exosomes with an excellent capability to regulate multiple cellular activities such as differentiation, development, metabolism, proliferation, apoptosis, and activation. With the advancements in transcriptomic and genomic study methods and database management technology, the functions and mechanisms of exosomal lncRNAs in liver diseases have been well-studied. This article delves into the detailed role of exosomal lncRNAs in liver disease onset and progression, ranging from hepatocellular carcinoma (HCC) to liver fibrosis drug-induced liver damage (DILI) and steatotic liver diseases.

Indexed as

ExosomesLiver DiseasesRNA, Long NoncodingAnimalsCarcinoma, HepatocellularHumansLiverLiver NeoplasmsRNA, Long NoncodingExosomesHepatocellular carcinomaLiver fibrosisLong non-coding RNAsPathogenesis

Identifiers

PMID39567423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.