Evidence map›Paper›PMID 39567333›Full record

ArticleUltrasound in medicine & biology2025

Acoustic Droplet Vaporization Efficiency and Oxygen Scavenging in Whole Blood.

Kateryna Stone, Nour Al Rifai, Demetria M Fischesser, John Dumancic, Shameel Abid, David Willett, Christy K Holland, Kevin J Haworth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kateryna StoneDepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Nour Al RifaiDepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Demetria M FischesserDepartment of Research and Development, Procter and Gamble, Cincinnati, OH, USA.
John DumancicDepartment of Physics, University of Cincinnati, Cincinnati, OH, USA.
Shameel AbidMedical Sciences Program, University of Cincinnati, Cincinnati, OH, USA.
David WillettDepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Christy K HollandDepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.
Kevin J HaworthDepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA; Medical Sciences Program, University of Cincinnati, Cincinnati, OH, USA; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA; Department of Pediatrics Heart Institute, University of Cincinnati, Cincinnati, OH, USA. Electronic address: hawortkn@ucmail.uc.edu.

Funding

Ultrasound-mediated Controlled Hypoxemic Reperfusion for Inhibition of Reperfusion InjuryR01HL148451 · NHLBI · UNIVERSITY OF CINCINNATI · PI HAWORTH, KEVIN JOSEPH · 2019 to 2023
$3.7M
ZE5 Analytical CytometerS10OD025045 · OD · CINCINNATI CHILDRENS HOSP MED CTR · PI THORNTON, SHERRY L · 2018 to 2018
$359k
NHLBI NIH HHS R01 HL148451NIH HHS S10 OD025045
6 · The paper itself

Abstract

objectiveAcoustic droplet vaporization (ADV) is the liquid-to-gas phase transition of perfluorocarbon (PFC) droplets to microbubbles upon ultrasound insonation. After ADV, gases dissolved in the surrounding fluid diffuse into microbubbles, enabling oxygen scavenging. Characterization of oxygen scavenging and transition efficiency (TE) in whole blood has so far been limited. In this work, oxygen scavenging and perfluorocarbon droplet TE in a saline buffer and whole bovine blood were evaluated using blood-gas analysis and flow cytometry.

methodsOxygen scavenging from whole blood via ADV was determined using an in vitro flow phantom with droplets comprising a phospholipid shell and either a decafluorobutane (DFB) or a perfluoropentane (PFP) core. Fluorescent droplets were used to determine ADV TE in whole blood via flow cytometry. Finally, a mathematical model predicting oxygen scavenging from whole blood was developed based on the experimental TE values.

resultsDFB droplets enabled greater oxygen scavenging and higher TE when compared with perfluoropentane droplets in both buffer and whole blood. Increasing the droplet concentration resulted in a greater amount of hemoglobin-bound and dissolved oxygen scavenging from whole blood. ADV of DFB droplets at a concentration of 5 × 10

conclusionIncreased oxygen scavenging and TE were achieved with DFB droplets relative to perfluoropentane droplets.

Indexed as

FluorocarbonsOxygenAcousticsAnimalsBlood Gas AnalysisCattleFlow CytometryMicrobubblesPentanesPhantoms, ImagingVolatilizationFluorocarbonsOxygenPentanesperfluoropentaneBlood gas analysisCoulter counterDecafluorobutaneFlow cytometryHemoglobinPerfluoropentane

Identifiers

PMID39567333
PMCPMC12043379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.