Evidence map›Paper›PMID 39567282›Full record

ReviewDrug metabolism and pharmacokinetics2025

Human brain organoids for understanding substance use disorders.

Kangle Li, Longjun Gu, Hongwei Cai, Hui-Chen Lu, Ken Mackie, Feng Guo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Drug metabolism and pharmacokinetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Organoid Brain-Machine-Interface Devices for Central Nervous System Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kangle LiDepartment of Intelligent Systems Engineering, Indiana University Bloomington, IN, 47405, USA.
Longjun GuDepartment of Intelligent Systems Engineering, Indiana University Bloomington, IN, 47405, USA.
Hongwei CaiDepartment of Intelligent Systems Engineering, Indiana University Bloomington, IN, 47405, USA.
Hui-Chen LuGill Center for Biomolecular Science, Department of Psychological and Brain Sciences, Indiana University Bloomington, IN, 47405, USA.
Ken MackieGill Center for Biomolecular Science, Department of Psychological and Brain Sciences, Indiana University Bloomington, IN, 47405, USA.
Feng GuoDepartment of Intelligent Systems Engineering, Indiana University Bloomington, IN, 47405, USA. Electronic address: fengguo@iu.edu.

Funding

An automated portable system for detecting and treating opioid induced respiratory depressionU01DA056242 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI GUO, FENG, MACKIE, KENNETH · 2022 to 2024
$3.8M
An acoustofluidic avidity cytometer for massive parallel profiling single autoreactive T cell in autoimmune diseaseDP2AI160242 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI GUO, FENG · 2020 to 2020
$2.4M
NIAID NIH HHS DP2 AI160242NIDA NIH HHS U01 DA056242
6 · The paper itself

Abstract

Substance use disorders (SUDs) are complex mental health conditions involving a problematic pattern of substance use. Challenges remain in understanding its neural mechanisms, which are likely to lead to improved SUD treatments. Human brain organoids, brain-like 3D in vitro cultures derived from human stem cells, show unique potential in recapitulating the response of a developing human brain to substances. Here, we review the recent progress in understanding SUD using human brain organoid models focusing on neurodevelopmental perspectives. We first summarize the background of SUD in humans. Moreover, we introduce the development of various human brain organoid models and then discuss current progress and findings underlying the abuse of substances like nicotine, alcohol, and other addictive drugs using organoid models. Furthermore, we review efforts to develop organ chips and microphysiological systems to engineer better human brain organoids for advancing SUD studies. Lastly, we conclude by elaborating on the current challenges and future directions of SUD studies using human brain organoids.

Indexed as

BrainOrganoidsSubstance-Related DisordersAnimalsHumansHuman brain organoidsNeurodevelopmentSubstance use disorderToxicology

Identifiers

PMID39567282
PMCPMC11825288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.