Evidence map›Paper›PMID 39567195›Full record

ArticleLife science alliance2025

Brain and behavioural anomalies caused by

Marianna Caterino, Debora Paris, Giulia Torromino, Michele Costanzo, Gemma Flore, Annabella Tramice, Elisabetta Golini, Silvia Mandillo, Diletta Cavezza, Claudia Angelini and 6 more

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marianna CaterinoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.
Debora ParisInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli (Naples), Italy.
Giulia TorrominoInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo (Rome), Italy.
Michele CostanzoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-6386-2009
Gemma FloreInstitute of Genetics and Biophysics of the National Research Council, Naples, Italy.ORCID 0000-0002-6058-2263
Annabella TramiceInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli (Naples), Italy.
Elisabetta GoliniInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo (Rome), Italy.
Silvia MandilloInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo (Rome), Italy.ORCID 0000-0002-4869-0974
Diletta CavezzaInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo (Rome), Italy.
Claudia AngeliniInstitute for Applied Mathematics "Mauro Picone," National Research Council, Naples, Italy.
Margherita RuoppoloDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.
Andrea MottaInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli (Naples), Italy.ORCID 0000-0002-8643-658X
Elvira De LeonibusInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo (Rome), Italy.
Antonio BaldiniDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-5330-0256
Elizabeth IllingworthDepartment of Chemistry and Biology University of Salerno, Fisciano, Italy eillingworth@unisa.it.ORCID 0000-0002-9079-9121
Gabriella LaniaInstitute of Genetics and Biophysics of the National Research Council, Naples, Italy gabriella.lania@igb.cnr.it.ORCID 0000-0003-3681-0251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain-related phenotypes observed in 22q11.2 deletion syndrome (DS) patients are highly variable, and their origin is poorly understood. Changes in brain metabolism might contribute to these phenotypes, as many of the deleted genes are involved in metabolic processes, but this is unknown. This study shows for the first time that

Indexed as

BrainDisease Models, AnimalHaploinsufficiencyT-Box Domain ProteinsVitamin B 12AnimalsBehavior, AnimalDiGeorge SyndromeFemaleHumansMaleMiceMice, Inbred C57BLPhenotypeT-Box Domain ProteinsTbx1 protein, mouseVitamin B 12

Identifiers

PMID39567195
PMCPMC11579592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.