ArticleJournal of the American College of Cardiology2024
Associations of Self-Reported Race, Social Determinants of Health, and Polygenic Risk With Coronary Heart Disease.
Article in Journal of the American College of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Sex-specific associations of social determinants of health and genetic risk factors with atherosclerotic cardiovascular diseases incidence in the general population.American journal of preventive cardiology · 2026Article
- Recommendations for return of secondary genomic findings in observational cohort studies.Nature genetics · 2026Review
- Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research.American journal of human genetics · 2026Review
- Social Determinants of Health and 1-Year Buprenorphine Initiation Among Justice-Involved Veterans.JAMA network open · 2026Article
- Mediation of coronary heart disease risk by genetic, socio-environmental, and lifestyle factors across racial groups.American journal of preventive cardiology · 2026Article
- Clinical use of polygenic risk scores: current status, barriers and future directions.Nature reviews. Genetics · 2026Review
- Social determinants disadvantage score and liver health in the All of Us Research Program.European journal of epidemiology · 2026Article
- Direct-to-Consumer Genetic Testing.NEJM evidence · 2025Review
- Analysis Impact of Positive Psychological Capital on Quality of Life Among Patients Post Percutaneous Coronary Intervention: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- The PRIMED Consortium: Reducing disparities in polygenic risk assessment.American journal of human genetics · 2024Article
- Considering Social and Genetic Factors in Cardiovascular Disease Risk.Journal of the American College of Cardiology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundSocial determinants of health (SDOH) influence the risk of common diseases such as coronary heart disease (CHD).
objectivesThis study sought to test the associations of self-reported race/ethnicity, SDOH, and a polygenic risk score (PRS), with CHD in a large and diverse U.S. COHORT:
methodsIn 67,256 All of Us (AoU) participants with available SDOH and whole-genome sequencing data, we ascertained self-reported race/ethnicity and 22 SDOH measures across 5 SDOH domains, and we calculated a PRS for CHD (PRS
resultsSDOH across 5 domains, including food insecurity, income, educational attainment, health literacy, neighborhood disorder, and loneliness, were associated with CHD. SDOH
conclusionsIncreased odds of CHD in people who self-report as Black are likely due to a higher SDOH burden. SDOH and PRS were independently associated with CHD. Our findings suggest that including both PRS and SDOH in CHD risk models could improve their accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.