Evidence map›Paper›PMID 39567020›Full record

ArticleJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi2024

Naloxone selectively inhibits vasoconstriction caused by phenylephrine but not endogenous noradrenaline in the rat mesenteric vasculature.

Muneaki Hidaka, Takayuki Matsumoto, Takayuki Nagano, Ryuichi Yamamoto, Naoko Tanaka-Totoribe

Abstract read
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In one paragraph

Article in Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muneaki HidakaThird Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Miyazaki 882-8508, Japan.
Takayuki MatsumotoSecond Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Miyazaki 882-8508, Japan.
Takayuki NaganoFirst Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Miyazaki 882-8508, Japan.
Ryuichi YamamotoFirst Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Miyazaki 882-8508, Japan.
Naoko Tanaka-TotoribeFirst Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Miyazaki 882-8508, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although naloxone is an antagonist of the opioid µ receptor, its effect on the peripheral sympathetic nerve function in the blood vessels has not yet been definitively elucidated. Therefore, we examined the effects of naloxone on vasoconstriction of the vascular smooth muscle of rats. Isolated rat mesenteric vascular-intestinal loop preparations were treated with either endogenous or exogenous α

Indexed as

NaloxoneNorepinephrinePhenylephrineVasoconstrictionAdrenergic alpha-1 Receptor AgonistsAnimalsIn Vitro TechniquesMaleMesenteric ArteriesMuscle, Smooth, VascularNarcotic AntagonistsPrazosinRatsRats, WistarVasoconstrictor AgentsAdrenergic alpha-1 Receptor AgonistsNaloxoneNarcotic AntagonistsNorepinephrinePhenylephrinePrazosinVasoconstrictor Agentsmesenteric vasculaturenaloxonenoradrenalinevasoconstrictionα1 adrenoceptor

Identifiers

PMID39567020
PMCPMC11578685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.