Evidence map›Paper›PMID 39566986›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Changes in Hepatic Density Due to Oral Amiodarone-induced Liver injury Shown by Computed Tomography.

Kenichi Kishimoto, Hiroshi Tobita, Masatoshi Kataoka, Tomotaka Yazaki, Akihiko Oka, Norihisa Ishimura, Kazuaki Tanabe, Shunji Ishihara

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kenichi KishimotoInternal Medicine II, Faculty of Medicine, Shimane University, Japan.
Hiroshi TobitaInternal Medicine II, Faculty of Medicine, Shimane University, Japan.
Masatoshi KataokaInternal Medicine II, Faculty of Medicine, Shimane University, Japan.
Tomotaka YazakiInternal Medicine II, Faculty of Medicine, Shimane University, Japan.
Akihiko OkaInternal Medicine II, Faculty of Medicine, Shimane University, Japan.
Norihisa IshimuraInternal Medicine II, Faculty of Medicine, Shimane University, Japan.
Kazuaki TanabeInternal Medicine IV, Faculty of Medicine, Shimane University, Japan.
Shunji IshiharaInternal Medicine II, Faculty of Medicine, Shimane University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amiodarone is an antiarrhythmic drug that is widely used for atrial fibrillation and other refractory arrhythmias. Although beneficial, its long-term administration is associated with adverse effects on various organs. One patient presented with amiodarone-induced liver injury, which led to liver failure. Computed tomography revealed a gradual increase in hepatic density over a long period following the initiation of amiodarone. Despite the discontinuation of the drug, the patient developed hepatic encephalopathy and subsequently died. This outcome highlights the drug's extended half-life, which caused persistent end-organ damage even after its withdrawal. Drug titration to the lowest effective dose and careful monitoring of annual liver function tests are important.

Indexed as

AmiodaroneAnti-Arrhythmia AgentsChemical and Drug Induced Liver InjuryLiverTomography, X-Ray ComputedAdministration, OralAgedAtrial FibrillationFatal OutcomeHumansMaleAmiodaroneAnti-Arrhythmia Agentsamiodaronehepatic density on computed tomographyliver injury

Identifiers

PMID39566986
PMCPMC12241720

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.