Observational studyBMJ open2024
Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan.
Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Association between oropharyngeal dysphagia and functional constipation in older adults: a cross-sectional study.Frontiers in public health · 2026Article
- Impact of constipation on patients with schizophrenia and depression: an internet-based survey (CONSIDER survey).Frontiers in psychiatry · 2026Article
- Postmarketing surveillance of elobixibat for patients with chronic constipation and concomitant schizophrenia or depression in Japan.Frontiers in psychiatry · 2026Article
- Depressive Symptoms, Dietary Patterns and Other Factors Associated with Constipation in Middle-Aged Adults from Kielce District in Poland: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Age-stratified diagnostic value of high-resolution anorectal manometry in women with severe rectocele: interactions between anal relaxation rate and maximum anal resting pressure.International journal of colorectal disease · 2025Article
- Metabolomics Insights into Gut Microbiota and Functional Constipation.Metabolites · 2025Review
- Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007-2010.BMC gastroenterology · 2025Article
- Dietary inflammation and socioeconomic status mediate depression-constipation link: a cross-sectional analysis of NHANES 2005-2010.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the prevalence, associated factors, treatment status and burden of constipation in workers with depression or anxiety. STUDY
designThis was a retrospective observational study using a pre-existing database.
settingClaims data from October to November 2022 and data from the survey conducted in November 2022 were extracted from the database.
participantsThis study included self-reported workers who completed the survey, after excluding those with major mental disorders diagnosed as distinct from depression or anxiety and constipation due to organic diseases identified by International Classification of Diseases (ICD-10) codes. OUTCOME MEASURES: The subjects were divided into three groups: treated depression/anxiety, untreated depression/anxiety and no depression/anxiety. The prevalence of constipation, factors associated with constipation and medications prescribed for constipation were analysed. Work productivity and quality of life (QOL) were compared between three subgroups based on constipation status: treated constipation, untreated constipation and no constipation subgroup.
resultsOf the 18 585 respondents in the analysis population, 950 respondents (5.1%) were classified into the treated depression/anxiety group, 6035 respondents (32.5%) into the untreated depression/anxiety group and the remaining respondents into the no depression/anxiety group (11 600 (62.4%)). The prevalence of constipation was 22.5% in the treated group, 22.3% in the untreated group and 10.4% in the no depression/anxiety group, respectively. Depression and anxiety severity were independently associated with an increased risk of constipation. In all groups, the most commonly prescribed drug class was osmotic laxatives. Work productivity and QOL tended to indicate a greater burden in the untreated constipation subgroup than in the treated or no constipation subgroups.
conclusionsThe prevalence of constipation was twice as high if workers had depression/anxiety. Considering that the comorbidity of constipation with mental disorders may increase multiple burdens, appropriate medical interventions are required to treat both mental (depression/anxiety) and physical (constipation) conditions. This should be widely recognised by physicians and employers.
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