Evidence map›Paper›PMID 39566722›Full record

ArticleContemporary clinical trials2025

A peer support intervention in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT): The STEPP randomized pilot trial design and methods.

Emma P Keane, Michelle Guo, Lisa M Gudenkauf, Annabella C Boardman, M Tim Song, Emma D Wolfe, Isabella S Larizza, Manfred N Mate-Kole, Brian C Healy, Jeff C Huffman and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
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In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06010017 (Peer Support Intervention for Patients Undergoing Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

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0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06010017 nacompletednot on this map

Peer Support Intervention for Patients Undergoing Hematopoietic Stem Cell Transplantation (STEPP): Feasibility and Preliminary Efficacy Trial

TypeinterventionalSponsorBrigham and Women's HospitalRan2024 to 2025Enrolled136ConditionsHematopoietic Neoplasms, Hematopoietic MalignancyArmsSTEPP Intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Emma P KeaneDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Michelle GuoDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Lisa M GudenkaufDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.
Annabella C BoardmanDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
M Tim SongDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Emma D WolfeDepartment of Health Services, University of Washington School of Public Health, Seattle, WA, USA.
Isabella S LarizzaDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Manfred N Mate-KoleHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Brian C HealyHarvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Jeff C HuffmanHarvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Areej El-JawahriHarvard Medical School, Boston, MA, USA; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA.
Hermioni L AmonooDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: hermioni_amonoo@dfci.harvard.edu.

Funding

A Positive Psychology Intervention for Allogeneic Stem Cell Transplant Patients.K08CA251654 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI AMONOO, HERMIONI L. · 2020 to 2024
$1.3M
NCI NIH HHS K08 CA251654
6 · The paper itself

Abstract

backgroundDespite the association between peer support interventions and improved patient-reported outcomes (PROs) across cancer populations, there is a lack of structured peer support interventions for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT).

objectiveTo test the feasibility, acceptability, and preliminary efficacy of a novel five-session, phone-delivered peer support intervention (STEPP: Supporting Transplant Experiences with Peer Program) for improving quality of life (QOL) and reducing psychological distress in patients undergoing HSCT.

methodsThis single-center pilot randomized clinical trial (RCT) will compare the STEPP intervention to usual transplant care among 90 patients hospitalized for HSCT. Eligible participants include adults (age ≥ 18 years) with hematologic malignancies hospitalized for autologous or allogeneic HSCT. The STEPP intervention provides informational, emotional, and practical support. To test the primary aim of intervention feasibility, we have established a priori benchmarks of 60 % enrollment of eligible patients and 60 % completion of at least 3 out of 5 intervention sessions among those randomized to STEPP. Acceptability will be assessed using the Client Satisfaction Questionnaire, with scores ≥3.0/4.0 indicating greater intervention acceptability. To test the secondary aim of preliminary efficacy, we will examine changes in PROs (e.g., anxiety symptoms and QOL) from pre- to post-intervention. DISCUSSION: This pilot RCT of a structured, phone-delivered peer support intervention tailored to the needs of patients preparing to undergo HSCT will elucidate the feasibility, acceptability, and preliminary efficacy of the STEPP intervention. We will then be poised to conduct a future, full-scale RCT to establish the efficacy of STEPP on patient outcomes. CLINICALTRIALS: gov: NCT06010017.

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationPeer GroupQuality of LifeRandomized Controlled Trials as TopicAdultAnxietyFeasibility StudiesFemaleHumansMalePatient Reported Outcome MeasuresPatient SatisfactionPilot ProjectsPsychological DistressSocial SupportCancerHematopoietic stem cell transplantationPeer mentorPeer supportQuality of lifeSocial support

Identifiers

PMID39566722
PMCPMC11700752

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.