Evidence map›Paper›PMID 39566720›Full record

ArticleContemporary clinical trials2025

Effect of donepezil on bone metabolism among older adults with Alzheimer's disease.

Rebecca North, Andy J Liu, Carl Pieper, Susanne Danus, Connie R Thacker, Marissa Ashner, Cathleen Colón-Emeric, Richard H Lee

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca NorthDuke University School of Medicine, Durham, NC, USA.
Andy J LiuDuke University School of Medicine, Durham, NC, USA.
Carl PieperDuke University School of Medicine, Durham, NC, USA.
Susanne DanusDuke University School of Medicine, Durham, NC, USA.
Connie R ThackerDuke University School of Medicine, Durham, NC, USA.
Marissa AshnerDuke University School of Medicine, Durham, NC, USA.
Cathleen Colón-EmericDuke University School of Medicine, Durham, NC, USA; Durham Veterans Administration Medical Center, Durham, NC, USA.
Richard H LeeDuke University School of Medicine, Durham, NC, USA; Durham Veterans Administration Medical Center, Durham, NC, USA. Electronic address: r.lee@duke.edu.

Funding

Effect of Acetylcholinesterase inhibitors on Bone Metabolism and Fracture Risk Factors among older adults with mild to moderate Alzheimer's DiseaseR21AG078982 · NIA · DUKE UNIVERSITY · PI LEE, RICHARD HSANG-YANG · 2023 to 2024
$439k
NIA NIH HHS R21 AG078982
6 · The paper itself

Abstract

Older adults with Alzheimer's disease (AD), in addition to significant cognitive disability, have twice the risk of fracture compared to those with normal cognition. Fractures among older adults with AD are associated with substantial morbidity, loss of physical function, and significant mortality. Prior studies have shown a decreased risk of fracture among those taking acetylcholinesterase inhibitors, such as donepezil. With both cognitive and non-cognitive benefits, donepezil would be a valuable component in a fracture prevention program for older adults with AD. Though anti-amyloid therapies are now clinically available, donepezil may still have non-cognitive benefits. However, the specific effects of donepezil on bone metabolism are unknown. We have designed this randomized, double-blind, placebo-controlled clinical trial to investigate the effect of AD treatment with donepezil on bone metabolism. The study will measure the change in bone mineral density, bone turnover markers, and bone quality related to 12-months of donepezil therapy. This will be the first known study of changes in bone metabolism among older adults with AD.

Indexed as

Alzheimer DiseaseBone DensityCholinesterase InhibitorsDonepezilAgedAged, 80 and overBone and BonesBone RemodelingDouble-Blind MethodFemaleFractures, BoneHumansIndansMaleRandomized Controlled Trials as TopicCholinesterase InhibitorsDonepezilIndansAlzheimer's diseaseBone metabolismBone mineral densityBone qualityBone turnover markersDonepezilOsteoporosis

Identifiers

PMID39566720
PMCPMC11700750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.