Evidence map›Paper›PMID 39565983›Full record

ArticleBlood2025

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics.

Alyssa C Parker, Joseph C Van Amburg, J Brett Heimlich, Yash Pershad, Nicole A Mickels, Taralynn M Mack, P Brent Ferrell, Michael R Savona, Angela L Jones, Alexander G Bick

Abstract read
In one paragraph

Article in Blood, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alyssa C ParkerProgram in Human Genetics, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-6632-7458
Joseph C Van AmburgProgram in Human Genetics, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-1410-6995
J Brett HeimlichDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-2812-5326
Yash PershadProgram in Human Genetics, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-2282-1403
Nicole A MickelsDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Taralynn M MackProgram in Human Genetics, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-1043-2950
P Brent FerrellDivision of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Michael R SavonaDivision of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-3763-5504
Angela L JonesVanderbilt Technologies for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN.
Alexander G BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

Funding

Investigating the role of the JAK/STAT3 Pathway in Clonal Proliferation and Immune Dysfunction in Myelodysplastic SyndromeK23HL138291 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERRELL, PAUL B · 2017 to 2021
$817k
Delineating Drivers of Inflammation and Progression in Clonal HematopoiesisR56DK138826 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERRELL, PAUL B · 2023 to 2023
$150k
NHLBI NIH HHS K23 HL138291NIDDK NIH HHS R56 DK138826
6 · The paper itself

Abstract

abstractWe have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared with interpretation based on variant allele fraction only.

Indexed as

Clonal HematopoiesisDNA MethylationHematopoiesisSequence Analysis, DNAHumans

Identifiers

PMID39565983
PMCPMC12782960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.