Evidence map›Paper›PMID 39565579›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Cardiomyocyte-Specific FoxO1 Knockout Mice as Tools to Assess Cardiac Hypertrophy and Key Experimental Considerations Using Cre-loxP.

Kate L Weeks, Julie R McMullen

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kate L WeeksDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, Australia. Kate.weeks@unimelb.edu.au.
Julie R McMullenBaker Department of Cardiometabolic Health, The University of Melbourne, Parkville, VIC, Australia. Julie.mcmullen@hri.org.au.

Funding

National Health and Medical Research Council 1078985National Health and Medical Research Council 526647
6 · The paper itself

Abstract

The generation of tissue-specific mouse models has provided a powerful strategy to understand the role of genes in specific tissues/cells of interest under control/basal conditions and in response to physiological and pathological stimuli. Here we describe the generation of cardiomyocyte-specific FoxO1 knockout mice using Cre-loxP technology to examine the role of FoxO1 for the induction of heart enlargement (cardiac hypertrophy) in settings of health and disease. We highlight breeding strategies for generating tissue-specific mouse models and key experimental considerations during characterization.

Indexed as

CardiomegalyDisease Models, AnimalForkhead Box Protein O1IntegrasesMice, KnockoutMyocytes, CardiacAnimalsMaleMiceCre recombinaseForkhead Box Protein O1Foxo1 protein, mouseIntegrasesCardiomyocyteCre-loxP technologyFoxO1Tissue-specific

Identifiers

PMID39565579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.