Evidence map›Paper›PMID 39565564›Full record

ArticleProbiotics and antimicrobial proteins2025

Improvement and Recovery of Intestinal Flora Disorder Caused by Ciprofloxacin Using Lactic Acid Bacteria.

Xiumin Su, Li Su, Mengyuan Cao, Yulu Sun, Jinghan Dai, Yuanjie He, Wei Li, Wupeng Ge, Xin Lv, Qiang Zhang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiumin Su *College of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Li Su *College of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Mengyuan CaoCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Yulu SunCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Jinghan DaiCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Yuanjie HeCollege of Life Science, Northwest A&F University, Yangling 712100, Xianyang, China.
Wei LiSchool of Biomedicine and Food Engineering, Shangluo University, Shangluo, 726000, Shaanxi, China.
Wupeng GeCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Xin LvCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Qiang ZhangCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China. zhqiang001@nwafu.edu.cn.
Shenghui CuiNational Institutes for Food and Drug Control, Beijing, 100050, China. cuishenghui@aliyun.com.
Jia ChenCollege of Chemical Technology, Shijiazhuang University, Shijiazhuang, 050035, China. chenjia_0311@163.com.
Baowei YangCollege of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China. ybwsheng@nwafu.edu.cn.

Funding

Department of Science and Technology of Shaanxi Province no. 2024JC-YBQN-0178Education Department of Shaanxi Provincial Government no. 22JHQ068Ministry of Science and Technology of the People's Republic of China no. 2022YFC2303900
6 · The paper itself

Abstract

In this study, four lactic acid bacteria (LAB) strains demonstrating ciprofloxacin, bile salt, gastric fluid, and intestinal fluid tolerance as well as adhesion ability to Caco-2 and HT-29 cells were used to improve and recover the intestinal flora disorders caused by ciprofloxacin, among which, Lactobacillus brevis 505 exhibited excellent adhesion ability to two kinds of cells and colonization ability to mouse intestinal. After ciprofloxacin treatment, certain recovery effect on cecum caused by ciprofloxacin in the mice was found during natural recovery (group 5C2), but it was challenging to fully restore the intestinal integrity to the initial level. After L. brevis 505 intervention (group 5C5), the intestinal damage to the colon and ileum caused by ciprofloxacin in mice was significantly alleviated; the recovery effect was better than that of natural recovery. Additionally, L. brevis 505 could effectively regulate INF-γ, sIgA, and RegIIIγ increase induced by ciprofloxacin. Shannon and Simpson index of the intestinal flora of mice in 5C5 group were higher than those in other group, the relative abundance of Bifidobacterium and Lactobacillus in the mice in 5C5 group was increased, indicating that LAB can better restore the structure and abundance of intestinal microflora. Consequently, L. brevis 505 shows promise as a probiotic for gut microbiota restoration and rebuilding during antibiotic therapy.

Indexed as

Anti-Bacterial AgentsCiprofloxacinGastrointestinal MicrobiomeLactobacillalesLevilactobacillus brevisProbioticsAnimalsBacterial AdhesionCaco-2 CellsHT29 CellsHumansMaleMiceAnti-Bacterial AgentsCiprofloxacinAntibioticIntestinal flora disorderLactic acid bacteriaMouse modelRecovery

Identifiers

PMID39565564

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.