ArticleBrain imaging and behavior2025
Links between brain structure and function in children with autism spectrum disorder by parallel independent component analysis.
Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A roadmap for conducting more inclusive research on brain resilience in ageing and dementia.Nature reviews. Neuroscience · 2026Review
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder accompanied by structural and functional changes in the brain. However, the relationship between brain structure and function in children with ASD remains largely obscure. In the current study, parallel independent component analysis (pICA) was performed to identify inter-modality associations by drawing on information from different modalities. Structural and resting-state functional magnetic resonance imaging data from 105 children with ASD and 102 typically developing children (obtained from the open-access Autism Brain Imaging Data Exchange database) were combined through the pICA framework. Features of structural and functional modalities were represented by the voxel-based morphometry (VBM) and amplitude of low-frequency fluctuations (ALFF), respectively. The relationship between the structural and functional components derived from the pICA was investigated by Pearson's correlation analysis, and between-group differences in these components were analyzed through the two-sample t-test. Finally, multivariate support vector regression analysis was used to analyze the relationship between the structural/functional components and Autism Diagnostic Observation Schedule (ADOS) subscores in the ASD group. This study found a significant association between VBM and ALFF components in ASD. Significant between-group differences were detected in the loading coefficients of the VBM component. Furthermore, the ALFF component loading coefficients predicted the subscores of communication and repetitive stereotypic behaviors of the ADOS. Likewise, the VBM component loading coefficients predicted the ADOS communication subscore in ASD. These findings provide evidence of a link between brain function and structure, yielding new insights into the neural mechanisms of ASD.
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Registered trials
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