Evidence map›Paper›PMID 39565442›Full record

ArticleMetabolic brain disease2024

The effect of paeoniflorin on the rewarding effect of methamphetamine and the associated cognitive impairment in mice.

Xin-Shuang Gong, Hai-Xing Wang, Xiang-Dong Yang, Zhao-Ying Yu, Shu-Jun Lin, Zhi-Ting Zou, Jia-Nan Lv, Li-Yin Qian, Yu-Er Ruan, Zi-Zhen Si and 2 more

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Article in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin-Shuang Gong *School of Public Health, Health Science Center, Ningbo University, Ningbo, 315211, China.
Hai-Xing Wang *National Narcotics Laboratory Zhejiang Regional Center, Hangzhou, China.
Xiang-Dong YangDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Zhao-Ying YuDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Shu-Jun LinDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Zhi-Ting ZouDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Jia-Nan LvSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Li-Yin QianSchool of Public Health, Health Science Center, Ningbo University, Ningbo, 315211, China.
Yu-Er RuanDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Zi-Zhen SiSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Yi ZhouNational Narcotics Laboratory Zhejiang Regional Center, Hangzhou, China.
Yu LiuSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China. liuyu@nbu.edu.cn.

Funding

Key Laboratory of Drug Monitoring and Control of Zhejiang Province 2022KLDMC007National Natural Science Foundation of China 81971247
6 · The paper itself

Abstract

Chronic exposure to methamphetamine (METH) has been suggested to cause METH use disorder and severe cognitive impairment. Paeoniflorin (PF) is a monoterpenoid glycoside with various beneficial effects, including anti-inflammatory, antioxidant and antidepressant. The current study was designed to investigate the effect of PF (30 mg/kg, i.p.) on the rewarding effect of METH (2.5 mg/kg, i.p.) and the associated cognitive impairment, using the animal model of conditioned place preference, new location reorganization test, new object reorganization test and Y-maze test. METH induced conditioned place preference, accompanied by increased expression of synapse-associated proteins in the ventral target areas (VTA) and nucleus accumbens (NAc). In addition, METH induced significant cognitive impairment and decreased the expression of synapse-associated proteins in the hippocampus (Hip). Administration of PF decreased the rewarding effect of METH and the expression of synapse-associated proteins in the VTA or NAc. PF was also effective to improve METH-induced cognitive impairment by upregulating the expression of synapse-associated proteins in the Hip. Therefore, PF could be a potential agent for the treatment of METH use disorder and the associated cognitive impairment.

Indexed as

Cognitive DysfunctionGlucosidesMethamphetamineMonoterpenesRewardAnimalsCentral Nervous System StimulantsGlycosidesHippocampusMaleMaze LearningMiceNucleus AccumbensVentral Tegmental AreaCentral Nervous System StimulantsGlucosidesGlycosidesMethamphetamineMonoterpenespeoniflorinMethamphetaminePaeoniflorinRewarding effectSynaptic proteinVTA

Identifiers

PMID39565442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.