ArticleMetabolic brain disease2024
Blood ammonia concentration measurement - effects of sampling site and cirrhosis during induced hyperammonaemia.
Article in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07273734 (A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Ursodeoxycholic Acid Plus Lactulose vs Lactulose Alone for the Prevention of Overt Hepatic Encephalopathy After TIPS Placement), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Ursodeoxycholic Acid Plus Lactulose vs Lactulose Alone for the Prevention of Overt Hepatic Encephalopathy After TIPS Placement
Who cites it
2 citing papers in PubMed.
- Effects of imbalanced gut microbial on mice with type a hepatic encephalopathy through the gut-liver-brain axis.Metabolic brain disease · 2026Article
- Oral Administration of L-Arginine Improves the Growth and Survival of Sow-Reared Intrauterine Growth-Restricted Piglets.Animals : an open access journal from MDPI · 2025Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAmmonia is implicated in hepatic encephalopathy (HE) and prognostic in cirrhosis. Venous ammonia concentration, yielding similar correlation with HE grades as arterial, has become the preferred practise but comparative data are limited.
aimTo quantify effect of sampling site on ammonia concentration in healthy persons and patients with cirrhosis.
methodsAmmonia concentrations were measured by arterial and femoral venous blood sampling in ten healthy men and ten male patients with cirrhosis before and during hyperammonaemia induced by ammonia infusion. Cubital vein samples were included during the infusion.
resultsAt baseline, arterial-venous concentration gaps were similar (p = 0.15) in healthy persons [14 (10-19) and 8 (4-12) µmol/L] and patients with cirrhosis [53 (32-74) and 40 (23-57) µmol/L]. Ammonia infusion increased arterial-venous concentration gaps in both groups [115 (97-133) and 61 (31-90) vs. 175 (123-227) and 134 (65-203) µmol/L]. Mean ammonia concentration difference between groups during hyperammonaemia was 72 (42-103) µmol/L (p < 0.001) and independent of sampling site. Cubital and femoral vein concentrations were comparable (p = 0.26). In cirrhosis, calculated upper limit normal values (ULN) were comparable for arterial and venous blood at baseline [2.0 (1.2-2.8) and 2.1 (1.2-3.0), p = 0.74] and during hyperammonaemia [6.7 (4.7-8.7) and 6.2 (4.4- 8.1), p = 0.44].
conclusionsWe found clinically meaningful intra-individual arterial-venous concentration gaps in both healthy persons and patients with cirrhosis at any ammonia concentration. Inter-group concentration differences after induced hyperammonaemia were relatively constant across sampling sites which supports clinical use of venous sampling. ULN-normalised ammonia concentrations were valid for both arterial and venous sampling.
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