Evidence map›Paper›PMID 39565202›Full record

ArticleNucleic acids research2025

InterPro: the protein sequence classification resource in 2025.

Matthias Blum, Antonina Andreeva, Laise Cavalcanti Florentino, Sara Rocio Chuguransky, Tiago Grego, Emma Hobbs, Beatriz Lazaro Pinto, Ailsa Orr, Typhaine Paysan-Lafosse, Irina Ponamareva and 24 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 649 papers.

0numbers the graph read from it
0cells of the map it votes in
649citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

649 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The phenotypic landscape of the model firmicuteProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

589 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Matthias BlumEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0001-5773-4724
Antonina AndreevaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-0450-0091
Laise Cavalcanti FlorentinoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Sara Rocio ChuguranskyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-0520-0736
Tiago GregoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-7946-7062
Emma HobbsEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-8470-4739
Beatriz Lazaro PintoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0001-6837-2941
Ailsa OrrEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Typhaine Paysan-LafosseEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0001-5663-0894
Irina PonamarevaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0009-0009-6041-5869
Gustavo A SalazarEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0001-9208-4966
Nicola BordinDepartment of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.ORCID 0000-0002-6568-9035
Peer BorkEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.ORCID 0000-0002-2627-833X
Alan BridgeSwiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva, Switzerland.ORCID 0000-0003-2148-9135
Lucy ColwellGoogle DeepMind, Cambridge, MA 02142, USA.ORCID 0000-0003-3148-0337
Julian GoughMedical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK.ORCID 0000-0002-1965-4982
Daniel H HaftNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0001-8101-4938
Ivica LetunicBiobyte Solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.ORCID 0000-0003-3560-4288
Felipe Llinares-LópezGoogle DeepMind, 75009 Paris, France.
Aron Marchler-BauerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0003-1516-0712
Laetitia Meng-PapaxanthosGoogle DeepMind, 8002 Zürich, Switzerland.ORCID 0000-0002-0521-621X
Huaiyu MiDivision of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0001-8721-202X
Darren A NataleProtein Information Resource, Georgetown University Medical Center, WA, DC 20007, USA.ORCID 0000-0001-5809-9523
Christine A OrengoDepartment of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.ORCID 0000-0002-7141-8936
Arun P PanduranganMedical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK.ORCID 0000-0001-7168-7143
Damiano PiovesanDepartment of Biomedical Sciences, University of Padova, Padova 35121, Italy.ORCID 0000-0001-8210-2390
Catherine RivoireSwiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva, Switzerland.ORCID 0000-0002-5979-8382
Christian J A SigristSwiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva, Switzerland.ORCID 0000-0002-4348-0070
Narmada ThankiNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0003-1181-2509
Françoise Thibaud-NissenNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0003-4957-7807
Paul D ThomasDivision of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-9074-3507
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padova, Padova 35121, Italy.ORCID 0000-0003-4525-7793
Cathy H WuProtein Information Resource, Georgetown University Medical Center, WA, DC 20007, USA.ORCID 0000-0001-6379-8601
Alex BatemanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-6982-4660

Funding

Gene Ontology Consortium and KnowledgebaseU24HG012212 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHRISTOPHER J MUNGALL, PAUL Warren STERNBERG · 2022 to 2026
$11.6M
Biotechnology and Biological Sciences Research Council BB/S020381/1European Molecular Biology LaboratoryItaliadomani-PNRR IR0000010National Center for BiotechnologyNHGRI NIH HHS U24 HG012212NIH HHSNLM NIH HHSWellcome TrustWellcome Trust 221 320/Z/20/Z
6 · The paper itself

Abstract

InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences into families. It integrates predictive models, known as signatures, from multiple member databases to classify sequences into families and predict the presence of domains and significant sites. The InterPro database provides annotations for over 200 million sequences, ensuring extensive coverage of UniProtKB, the standard repository of protein sequences, and includes mappings to several other major resources, such as Gene Ontology (GO), Protein Data Bank in Europe (PDBe) and the AlphaFold Protein Structure Database. In this publication, we report on the status of InterPro (version 101.0), detailing new developments in the database, associated web interface and software. Notable updates include the increased integration of structures predicted by AlphaFold and the enhanced description of protein families using artificial intelligence. Over the past two years, more than 5000 new InterPro entries have been created. The InterPro website now offers access to 85 000 protein families and domains from its member databases and serves as a long-term archive for retired databases. InterPro data, software and tools are freely available.

Indexed as

Databases, ProteinProteinsSequence Analysis, ProteinSoftwareAmino Acid SequenceInternetMolecular Sequence AnnotationUser-Computer InterfaceProteins

Identifiers

PMID39565202
PMCPMC11701551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.