Evidence map›Paper›PMID 39565190›Full record

ArticleeLife2024

NE contribution to rebooting unconsciousness caused by midazolam.

LeYuan Gu, WeiHui Shao, Lu Liu, Qing Xu, YuLing Wang, JiaXuan Gu, Yue Yang, ZhuoYue Zhang, YaXuan Wu, Yue Shen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Neuro-Cancer Interactions Shape Glioma Intratumoral Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

LeYuan Gu *Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.
WeiHui Shao *Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Lu Liu *Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.
Qing Xu *Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.
YuLing Wang *Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
JiaXuan Gu *Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Yue YangDepartment of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
ZhuoYue ZhangDepartment of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.
YaXuan WuDepartment of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0009-0009-3484-0589
Yue ShenDepartment of Anesthesiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China.
Qian YuDepartment of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
XiTing LianDepartment of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.
HaiXiang MaMedical College of Jining Medical University, Shandong, China.
YuanLi ZhangDepartment of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
HongHai ZhangDepartment of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0003-3530-2060

Funding

National Natural Science Foundation of China 81771403National Natural Science Foundation of China 81974205Natural Science Foundation of Zhejiang Province LHZY24H090003Natural Science Foundation of Zhejiang Province LZ20H090001
6 · The paper itself

Abstract

The advent of midazolam holds profound implications for modern clinical practice. The hypnotic and sedative effects of midazolam afford it broad clinical applicability. However, the specific mechanisms underlying the modulation of altered consciousness by midazolam remain elusive. Herein, using pharmacology, optogenetics, chemogenetics, fiber photometry, and gene knockdown, this in vivo research revealed the role of locus coeruleus (LC)-ventrolateral preoptic nucleus noradrenergic neural circuit in regulating midazolam-induced altered consciousness. This effect was mediated by α1 adrenergic receptors. Moreover, gamma-aminobutyric acid receptor type A (GABAA-R) represents a mechanistically crucial binding site in the LC for midazolam. These findings will provide novel insights into the neural circuit mechanisms underlying the recovery of consciousness after midazolam administration and will help guide the timing of clinical dosing and propose effective intervention targets for timely recovery from midazolam-induced loss of consciousness.

Indexed as

Hypnotics and SedativesMidazolamUnconsciousnessAnimalsConsciousnessLocus CoeruleusMaleMiceNorepinephrineOptogeneticsPreoptic AreaReceptors, Adrenergic, alpha-1Receptors, GABA-AHypnotics and SedativesMidazolamNorepinephrineReceptors, Adrenergic, alpha-1Receptors, GABA-AC57BL/6J mice femaleC57BL/6J mice maleGABAA-R knockdown C57BL/6J micemedicinemouseneuroscience

Identifiers

PMID39565190
PMCPMC11578583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.