Evidence map›Paper›PMID 39565120›Full record

ArticlemSystems2024

Cigarette smoke-induced disordered microbiota aggravates the severity of influenza A virus infection.

Tsering Wüthrich, Simone de Brot, Veronica Richina, Nadja Mostacci, Zora Baumann, Nathan G F Leborgne, Aurélie Godel, Marco P Alves, Mohamed Bentires-Alj, Charaf Benarafa and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tsering WüthrichInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Simone de BrotCOMPATH, Institute of Animal Pathology, University of Bern, Bern, Switzerland.
Veronica RichinaDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Nadja MostacciInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Zora BaumannDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Nathan G F LeborgneInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Aurélie GodelInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Marco P AlvesInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Mohamed Bentires-AljDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Charaf Benarafa *Institute of Virology and Immunology, Mittelhäusern, Switzerland.ORCID 0000-0002-2049-7769
Markus Hilty *Institute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID 0000-0002-2418-6474

Funding

Swiss National Science Foundation 173137Swiss National Science Foundation 197083University of Bern UniBE ID grant
6 · The paper itself

Abstract

Cigarette smoke (CS) promotes the development of chronic pulmonary disease and has been associated with increased risk for influenza-related illness. Here, we directly addressed the impact of CS disordered microbiota on the severity of influenza A virus (IAV) infection. Specific and opportunistic pathogen-free (SOPF) C57BL/6J mice were exposed to CS or room air (RA) for 5.5 months. Each exposed mouse was then cohoused with a group of recipient germ-free (GF) mice for 1 month for microbial transfer. Colonized GF mice were then infected intranasally with IAV and disease development was monitored. Upper and lower airway and fecal microbiota were longitudinally investigated by 16S rRNA gene sequencing and bacterial cultures in donor and recipient mice. The bacterial family

Indexed as

Mice, Inbred C57BLMicrobiotaOrthomyxoviridae InfectionsAnimalsFecesFemaleGastrointestinal MicrobiomeInfluenza A virusInfluenza A Virus, H1N1 SubtypeMaleMiceSeverity of Illness Indexairwayscigarette smokefecesgerm free miceH1N1 infectionmicrobiota

Identifiers

PMID39565120
PMCPMC11651097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.