Evidence map›Paper›PMID 39565116›Full record

ArticleAntimicrobial agents and chemotherapy2025

Durlobactam to boost the clinical utility of standard of care β-lactams against

Dereje A Negatu, Wassihun Wedajo Aragaw, Tewodros T Gebresilase, Sindhuja Paruchuri, Firat Kaya, Sung Jae Shin, Peter Sander, Véronique Dartois, Thomas Dick

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dereje A NegatuCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Wassihun Wedajo AragawCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Tewodros T GebresilaseArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Sindhuja ParuchuriCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Firat KayaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Sung Jae ShinDepartment of Microbiology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea.ORCID 0000-0003-0854-4582
Peter SanderInstitut für Medizinische Mikrobiologie, Universitat Zurich Institut fur Medizinische Mikrobiologie, Zürich, Switzerland.ORCID 0000-0003-1581-0682
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9470-5009
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-9604-9452

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
Shorter and more effective oral regimens for M. abscessus pulmonary diseaseR01AI184502 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI Thomas Dick · 2025 to 2026
$1.8M
HHS | National Institutes of Health (NIH) R01-AII132374NIAID NIH HHS R01 AI132374NIAID NIH HHS R01 AI184502
6 · The paper itself

Abstract

β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of pulmonary infections caused by

Indexed as

Anti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamsLung DiseasesMycobacterium abscessusMycobacterium Infections, NontuberculousSulbactamAnimalsCefoxitinDrug SynergismHumansImipenemMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamsCefoxitinImipenemSulbactamdrug resistancelung infectionMmpL11MspAMycobacterium abscessusRshAβ-lactams

Identifiers

PMID39565116
PMCPMC11784023

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.