Evidence map›Paper›PMID 39564863›Full record

Trial reportAmerican journal of hematology2025

Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.

Kadère Konté, Liza Afzali-Hashemi, Koen P A Baas, Anouk Schrantee, John C Wood, Erfan Nur, Aart J Nederveen, Bart J Biemond

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kadère KontéDepartment of Clinical Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-6637-0352
Liza Afzali-HashemiDepartment of Clinical Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Koen P A BaasDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Anouk SchranteeDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
John C WoodDivision of Cardiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-0996-3439
Erfan NurDepartment of Clinical Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Aart J NederveenDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Bart J BiemondDepartment of Clinical Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-4426-5743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease (SCD) is complicated by silent cerebral infarcts (SCIs), for which anemia is an important risk factor. Despite normal oxygen delivery (OD), cerebral vascular reserve (CVR), and cerebral metabolic rate of oxygen (CMRO

Indexed as

Anemia, Sickle CellCerebrovascular CirculationOxygenAdultBenzaldehydesBrainFemaleHemolysisHumansMagnetic Resonance ImagingMaleMiddle AgedNatriuretic Peptide, BrainOxygen ConsumptionPeptide FragmentsPyrazinesBenzaldehydesNatriuretic Peptide, BrainOxygenPeptide Fragmentspro-brain natriuretic peptide (1-76)PyrazinesPyrazolesvoxelotor

Identifiers

PMID39564863
PMCPMC11625979

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.