Evidence map›Paper›PMID 39564438›Full record

ArticleTurkish journal of emergency medicine

The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024.

Gökhan Aksel, Şeref Kerem Çorbacıoğlu, Mehmet Muzaffer İslam, Alp Şener, Fatma Nur Karaarslan, Merve Osoydan Satıcı, Enis Ademoğlu, Resul Çinpolat, Haldun Akoğlu, Faruk Danış and 5 more

Abstract read
In one paragraph

Article in Turkish journal of emergency medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gökhan AkselDepartment of Emergency Medicine, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-5580-3201
Şeref Kerem ÇorbacıoğluDepartment of Emergency Medicine, Atatürk Sanatoryum Training and Research Hospital, Ankara, Türkiye.ORCID https://orcid.org/0000-0001-7802-8087
Mehmet Muzaffer İslamDepartment of Emergency Medicine, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Türkiye.ORCID https://orcid.org/0000-0001-6928-2307
Alp ŞenerDepartment of Emergency Medicine, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye.ORCID https://orcid.org/0000-0002-0583-2936
Fatma Nur KaraarslanDepartment of Emergency Medicine, Manisa Soma State Hospital, Manisa, Türkiye.ORCID https://orcid.org/0000-0003-4465-9598
Merve Osoydan SatıcıDepartment of Emergency Medicine, University of Health Sciences Sisli Hamidiye Etfal Research and Training Hospital, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-3169-0724
Enis AdemoğluDepartment of Emergency Medicine, Gaziantep City Hospital, Gaziantep, Türkiye.ORCID https://orcid.org/0000-0002-6330-666X
Resul ÇinpolatDepartment of Emergency Medicine, Tokat State Hospital, Tokat, Türkiye.ORCID https://orcid.org/0000-0003-4897-4659
Haldun AkoğluDepartment of Emergency Medicine, Marmara University School of Medicine, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-1316-0308
Faruk DanışDepartment of Emergency Medicine, Bolu Abant İzzet Baysal University Medical School, Bolu, Türkiye.ORCID https://orcid.org/0000-0001-8722-5402
Fatma Sarı DoğanDepartment of Emergency Medicine, University of Health Sciences, Fatih Sultan Mehmet Education and Research Hospital, İstanbul, Türkiye.ORCID https://orcid.org/0000-0002-3790-9774
Emre KuduDepartment of Emergency Medicine, Marmara University Pendik Training and Research Hospital, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-1422-5927
Murtaza KayaDepartment of Emergency Medicine, Kütahya Health Sciences University, Kütahya City Hospital, Kütahya, Türkiye.ORCID https://orcid.org/0000-0003-4012-4131
Emir ÜnalDepartment of Emergency Medicine, Marmara University Pendik Training and Research Hospital, Istanbul, Türkiye.ORCID https://orcid.org/0000-0003-2758-8214
Kamil KayayurtDepartment of Medical Education, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Türkiye.ORCID https://orcid.org/0000-0001-6984-3063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical policy of the Emergency Medicine Association of Türkiye (EMAT) provides guidance on the use of tranexamic acid (TXA) in emergency settings. TXA, an antifibrinolytic drug, is used to control bleeding by inhibiting plasminogen. Its applications have expanded from hemophilia and severe menstrual bleeding to include various forms of trauma and surgery-related bleeding. Despite its potential benefits, the use of TXA in emergency settings must be carefully evaluated due to its associated risks, including venous thromboembolism. This policy aimed to offer evidence-based recommendations on the indications and contraindications of TXA in different clinical scenarios encountered in the emergency departments. The guidelines were developed using the "Grading of Recommendations, Assessment, Development, and Evaluations" approach, incorporating systematic literature reviews, and expert consensus from the EMAT Research Committee. This document focuses on critical clinical questions regarding the efficacy and safety of TXA in situations such as gastrointestinal bleeding, multitrauma, traumatic brain injury, nontraumatic intracranial hemorrhage, hemoptysis, and epistaxis. By addressing these issues, the policy seeks to assist emergency physicians in making informed decisions about the use of TXA, ultimately aiming to improve the patient outcomes.

Indexed as

Brain injuryemergency departmentepistaxisgastrointestinal bleedinghemoptysisintracranial hemorrhagepolicytranexamic acidtrauma

Identifiers

PMID39564438
PMCPMC11573170

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.