Evidence map›Paper›PMID 39564196›Full record

ArticleInternational journal of developmental disabilities2024

Diet and physical activity modification: impact on adaptive behavior and biochemical measures of children with Down syndrome.

Ayman Kilany, Mohamed E Elhadidy, Mona M F Ganem, Neveen Hassan Nashaat, Ghada Orabi, Mohamed A Sakr

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Article in International journal of developmental disabilities, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayman KilanyResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-3157-8396
Mohamed E ElhadidyResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0001-7830-9145
Mona M F GanemMedical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0003-4189-8809
Neveen Hassan NashaatResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0003-1553-9327
Ghada OrabiResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
Mohamed A SakrDepartment of Neurology, Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt.ORCID https://orcid.org/0000-0002-9481-5547

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Obesity in children with Down syndrome (DS) has negative implications for behavior. The aim was to assess the influence of weight reduction by diet modification with and without physical therapy sessions on adaptive behavior and some biochemical measures in children with DS with obesity. Methods: The study included 100 children with DS (56 males, 44 females; age range: 6-9 (8.5 ± 1.7) years. They were subjected to history taking, clinical examination, and the Vineland adaptive behavior scale. They were randomly divided into two groups: Group I underwent nutritional modification, and Group II was subjected to an added exercise program. The biochemical measures were estimated using the automated chemistry analyzer for blood chemistry (lipids), or ELISA. Results: An elevation of behavioral adaptive scores was noticed after the weight reduction, together with a reduction in the levels of triglycerides and an elevation of high-density lipoprotein-C levels. Levels of interleukin I, interleukin 6, and leptin were reduced in both groups. However, the improvement regarding the estimated measures was greater in Group II ( Conclusions: Weight reduction in children with DS was beneficial for their adaptive behavior and for adjusting dyslipidemia, along with some measures of inflammation. Combining physical activity with nutritional modification would help in the better advancement of the health and adaptive behavior of children with DS associated with obesity compared with isolated nutritional modification.

Indexed as

adaptive behaviorDown syndromeinterleukinslipidsobesity

Identifiers

PMID39564196
PMCPMC11571723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.