ArticleWorld journal of psychiatry2024
Family functioning mediation in tic severity and quality of life for children with Tourette syndrome.
Article in World journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- White matter microstructural abnormalities in children with Tourette syndrome using tract-based spatial statistics analysis.Japanese journal of radiology · 2026Article
- Tic severity and quality of life in children with tic disorders: the chain mediating effects of stigma and anxiety.Frontiers in psychiatry · 2026Article
- Environmental moderators of tic severity and quality of life in children with tic disorders.European journal of pediatrics · 2025Article
- Subtypes of tic disorders in children and adolescents: based on clinical characteristics.BMC pediatrics · 2025Article
- Growing up with tic disorders: an Italian survey on quality of life and access to care.Frontiers in psychiatry · 2025Article
- The clinical features and initial pharmacotherapeutic options of children with Tic disorders.Frontiers in pediatrics · 2025Article
- Advances in Clustering and Classification of Tic Disorders: A Systematic Review.Neuropsychiatric disease and treatment · 2024Review
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Authors and funding
7 authors.
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Abstract
backgroundTourette syndrome (TS) is recognized as a neurodevelopmental disorder profoundly influenced by familial factors, particularly family functioning. However, the relationship among family functioning, tic severity, and quality of life in individuals with TS during childhood and adolescence remains unclear. We hypothesized that family functioning plays a role in the association between the severity of TS and quality of life in children.
aimTo determine the role of family functioning in the relationship between TS severity and quality of life.
methodsThis study enrolled 139 children (male/female = 113/26) with TS. We assessed tic severity using the Yale Global Tic Severity Scale, quality of life
resultsWe found that family communication dysfunction had a significant mediating effect between tic severity and both psychological symptoms (indirect effect: Β = 0.0038, 95% confidence interval: 0.0006-0.0082) as well as physical and activities of daily living impairment (indirect effect: Β = 0.0029, 95% confidence interval: 0.0004-0.0065). For vocal tic severity, this mediation was found to be even more pronounced. Additionally, in male participants and those without attention deficit hyperactivity disorder, the mediating effect of family communication dysfunction was still evident.
conclusionOur study highlights the impact of family functioning on the tic severity and the quality of life in children. This relationship is influenced by gender and comorbid conditions like attention deficit hyperactivity disorder.
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