Evidence map›Paper›PMID 39563905›Full record

ArticleEuropean heart journal. Digital health2024

Prediction of cardiovascular markers and diseases using retinal fundus images and deep learning: a systematic scoping review.

Livie Yumeng Li, Anders Aasted Isaksen, Benjamin Lebiecka-Johansen, Kristian Funck, Vajira Thambawita, Stine Byberg, Tue Helms Andersen, Ole Norgaard, Adam Hulman

Abstract readScoping Review
In one paragraph

Article in European heart journal. Digital health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  3. Article
  4. Article
  5. Predicting stroke risk using retinal imaging with artificial intelligence: a scoping review of current evidence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  6. Review
  7. The role of artificial intelligence in hypertension management.Current opinion in nephrology and hypertension · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Livie Yumeng LiDepartment of Public Health, Aarhus University, Bartholins Allé 2, 8000 Aarhus C, Denmark.ORCID https://orcid.org/0009-0000-8579-6228
Anders Aasted IsaksenSteno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.
Benjamin Lebiecka-JohansenSteno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.
Kristian FunckSteno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.
Vajira ThambawitaDepartment of Holistic Systems, SimulaMet, Stensberggata 27, 0170 Oslo, Norway.
Stine BybergClinical Epidemiological Research, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.
Tue Helms AndersenDepartment of Education, Danish Diabetes Knowledge Center, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.
Ole NorgaardDepartment of Education, Danish Diabetes Knowledge Center, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.
Adam HulmanDepartment of Public Health, Aarhus University, Bartholins Allé 2, 8000 Aarhus C, Denmark.ORCID https://orcid.org/0000-0002-3969-1000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid development in deep learning for image analysis inspired studies to focus on predicting cardiovascular risk using retinal fundus images. This scoping review aimed to identify and describe studies using retinal fundus images and deep learning to predict cardiovascular risk markers and diseases. We searched MEDLINE and Embase on 17 November 2023. Abstracts and relevant full-text articles were independently screened by two reviewers. We included studies that used deep learning for the analysis of retinal fundus images to predict cardiovascular risk markers or cardiovascular diseases (CVDs) and excluded studies only using predefined characteristics of retinal fundus images. Study characteristics were presented using descriptive statistics. We included 24 articles published between 2018 and 2023. Among these, 23 (96%) were cross-sectional studies and eight (33%) were follow-up studies with clinical CVD outcomes. Seven studies included a combination of both designs. Most studies (96%) used convolutional neural networks to process images. We found nine (38%) studies that incorporated clinical risk factors in the prediction and four (17%) that compared the results to commonly used clinical risk scores in a prospective setting. Three of these reported improved discriminative performance. External validation of models was rare (21%). There is increasing interest in using retinal fundus images in cardiovascular risk assessment with some studies demonstrating some improvements in prediction. However, more prospective studies, comparisons of results to clinical risk scores, and models augmented with traditional risk factors can strengthen further research in the field.

Indexed as

Cardiovascular diseaseCardiovascular riskClinical predictionDeep learningRetinal fundus imageSystematic scoping review

Identifiers

PMID39563905
PMCPMC11570365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.