ArticleiScience2024
Fabrication of crosslinker free hydrogels with diverse properties: An interplay of multiscale physical forces within polymer matrix.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2-Deoxyglucose.Angewandte Chemie (International ed. in English) · 2026Article
- Bacterial ghosts embedded in natural hydrogels as drug delivery vehicles for cancer treatment.RSC advances · 2026Article
- Effect of Cinnamaldehyde Addition on Injectable Gypsum-Calcium Carbonate Hydrogel Paste with Ultraviolet Light Polymerization: Bone Scaffold Material for Implant.European journal of dentistry · 2026Article
- Natural Polymers Based Biocompatible Nanomedicines for Targeting Colon Cancer: Prospects and Challenges.International journal of nanomedicine · 2026Review
- Strategies for Regulating the Release Kinetics of Bioactive Compounds from Biopolymeric Hydrogels.Gels (Basel, Switzerland) · 2025Review
- Hydrogels for Climate Change Mitigation: Applications in Water Harvesting, Passive Cooling, and Environmental Solutions.Gels (Basel, Switzerland) · 2025Review
- Freeze-Dried Chitosan Scaffolds Containing Grape Seed Oil for Wound Healing Applications.ACS omega · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical/chemical crosslinking and surface-modifications of hydrogels have been extensively endorsed to enhance their biomaterial functionalities. The latter approaches involve using toxic crosslinkers or chemical modifications of the biopolymers, limiting the clinical translation of hydrogels beyond short-term promising results. The current study aims to tailor the polymer's structure to obtain customized applications using the same FDA-approved ingredients. PEGs of different molecular weights have been used to tune the van der Waal's forces, NaCl has been used to alter the electrostatic interactions of the charged polymers, and glycerol has been used to tweak the H-bonding. Same crosslinker-free sodium alginate/gelatin hydrogel formulation unfolds multiple properties: controlled-release, self-healing, mesh size, storage modulus, degradation rate. The hydrogels, lacking in one aspect, displayed superior performance in another. This study, including experiments and molecular simulations, illustrates that developing new materials may not always be necessary, as the same polymeric matrix can generate immense variations in different aspects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.