Evidence map›Paper›PMID 39563895›Full record

ArticleiScience2024

Direct activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases.

Li She, Hamad H Alanazi, Yimin Xu, Yuxuan Yu, Yuzhang Gao, Shuting Guo, Qingquan Xiong, Hui Jiang, Kexin Mo, Jingwei Wang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Li SheDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Hamad H AlanaziDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Yimin XuDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Yuxuan YuDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Yuzhang GaoDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Shuting GuoSino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, 1 Xinzao Road, Guangzhou, Guangdong 511495, China.
Qingquan XiongSino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, 1 Xinzao Road, Guangzhou, Guangdong 511495, China.
Hui JiangDepartment of Gynecology, The Fifth Affiliated Hospital, Guangzhou Medical University, 621 Gangwan Road, Guangzhou, Guangdong 510700, China.
Kexin MoDepartment of Gynecology, The Fifth Affiliated Hospital, Guangzhou Medical University, 621 Gangwan Road, Guangzhou, Guangdong 510700, China.
Jingwei WangDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Daniel P ChuppDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Hong ZanDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Zhenming XuDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Yilun SunDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Na XiongDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Nu ZhangDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Zhihai XieDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Weihong JiangDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Xin ZhangDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Yong LiuDepartment of Otolaryngology-Head and Neck Surgery, Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders, Otolaryngology Major Disease Research Key Laboratory of Hunan Province, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Xiao-Dong LiDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group 2 innate lymphoid cells (ILC2s) are key players in type 2 immunity, but whether they can be directly activated by microbial ligands remain uncertain. In this study, we observed a positive correlation between blood endotoxin (LPS) levels and circulating ILC2s in allergic patients.

Indexed as

Cell biologyImmunologyPathophysiology

Identifiers

PMID39563895
PMCPMC11574794

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.