Evidence map›Paper›PMID 39563890›Full record

ArticleiScience2024

Early synaptic dysfunction of striatal parvalbumin interneurons in a mouse model of Parkinson's disease.

Quansheng He, Xiaowen Zhang, Hongyu Yang, Dahui Wang, Yousheng Shu, Xuan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Quansheng HeInstitute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China.
Xiaowen ZhangInstitute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China.
Hongyu YangSchool of Systems Science, Beijing Normal University, Beijing 100875, China.
Dahui WangSchool of Systems Science, Beijing Normal University, Beijing 100875, China.
Yousheng ShuInstitute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China.
Xuan WangDepartment of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Parkinson's disease (PD), the loss of dopaminergic signaling remodels striatal circuits, causing abnormal network activity. The timing and impact on various striatal cell types during this reorganization are unclear. Here we demonstrate that dopamine depletion rapidly reduces parvalbumin (PV) expression. At the synaptic input level, PV interneurons shift toward inhibition in the excitation-inhibition balance early on, a week before a similar shift in spiny projection neurons (SPNs). At the cellular level, both PV interneurons and SPNs experience a significant decrease in their spiking and bursting rates, respectively, which corresponds to a reduction in gamma and beta (

Indexed as

Cellular neuroscienceNeurosciencePathophysiology

Identifiers

PMID39563890
PMCPMC11575173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.