Evidence map›Paper›PMID 39563831›Full record

ArticleACS medicinal chemistry letters2024

Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1

Xinrui Yuan, Jason C Rech, Andhavaram Ramaraju, Amol D Patil, Krishani Rajanayake, Hebao Yuan, Mona Kazemi Sabzvar, Mousumi Mandal, Eun Bee Cho, Bo Wen and 5 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xinrui YuanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Jason C RechDepartment of Internal Medicine, Hematology and Oncology, Michigan Center for Therapeutic Innovation, Ann Arbor, Michigan 48109, United States.
Andhavaram RamarajuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Amol D PatilDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Krishani RajanayakeCollege of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Hebao YuanCollege of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0003-4425-3678
Mona Kazemi SabzvarDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Mousumi MandalDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.ORCID https://orcid.org/0000-0001-8131-1668
Eun Bee ChoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Bo WenCollege of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jianxiong JiangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.ORCID https://orcid.org/0000-0003-3955-8928
M Dennis LeoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Udai P SinghDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Duxin SunCollege of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0002-6406-2126
Chao-Yie YangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.ORCID https://orcid.org/0000-0002-5445-0109

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Inflammatory regulation of neurotrophin signaling in epileptogenesisR01NS100947 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Jianxiong Jiang · 2018 to 2026
$2.8M
Development of first-in-class ST2 inhibitors for treating graft-versus-host diseaseR01HL141432 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PACZESNY, SOPHIE, YANG, CHAO-YIE · 2019 to 2022
$2.6M
Adipose T cell microRNAs (miRs) regulate macrophage function during obesityR01AI140405 · NIAID · UNIVERSITY OF VIRGINIA · PI SINGH, UDAI P. · 2020 to 2025
$1.9M
NCI NIH HHS P30 CA046592NHLBI NIH HHS R01 HL141432NIAID NIH HHS R01 AI140405NINDS NIH HHS R01 NS100947
6 · The paper itself

Abstract

ST2 belongs to the interleukin 1 receptor family and is expressed in immune cells including certain CD4

Identifiers

PMID39563831
PMCPMC11571090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.