Evidence map›Paper›PMID 39563818›Full record

ArticleACS medicinal chemistry letters2024

Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies.

Silvia Salerno, Elisabetta Barresi, Michele Roggia, Benito Natale, Simona Marzano, Mariafrancesca Hyeraci, Serena Concetta Rita Reina, Emma Baglini, Jussara Amato, Erica Salvati and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Silvia SalernoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.ORCID https://orcid.org/0000-0002-6072-4698
Elisabetta BarresiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.ORCID https://orcid.org/0000-0002-9814-7195
Michele RoggiaDiSTABiF, Università della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID https://orcid.org/0009-0009-3860-2502
Benito NataleDiSTABiF, Università della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID https://orcid.org/0009-0002-2065-2535
Simona MarzanoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Mariafrancesca HyeraciDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua via F. Marzolo 5, 35131 Padova, Italy.
Serena Concetta Rita ReinaInstitute of Molecular Biology and Pathology, National Research Council, Via degli Apuli 4, 00185 Rome, Italy.ORCID https://orcid.org/0009-0008-9409-0057
Emma BagliniCNR IFC, Institute of Clinical Physiology, National Research Council of Italy, CNR Research Area, Via G. Moruzzi 1, Pisa 56124, Italy.
Jussara AmatoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0001-6096-3544
Erica SalvatiInstitute of Molecular Biology and Pathology, National Research Council, Via degli Apuli 4, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-3373-7442
Lisa Dalla ViaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua via F. Marzolo 5, 35131 Padova, Italy.ORCID https://orcid.org/0000-0002-9828-9388
Federico Da SettimoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.ORCID https://orcid.org/0000-0002-7897-7917
Sandro CosconatiDiSTABiF, Università della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID https://orcid.org/0000-0002-8900-0968
Sabrina TalianiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.ORCID https://orcid.org/0000-0001-8675-939X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we explored the benzothiopyranoindole scaffold to develop antiproliferative agents with a polypharmacological profile targeting both G-quadruplex (G4)-structures and Topoisomerase (Topo) I enzyme. In a preliminary optimization phase, compound

Identifiers

PMID39563818
PMCPMC11571019

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.