Evidence map›Paper›PMID 39563792›Full record

ArticleACS medicinal chemistry letters2024

Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors.

Daniele Pala, Paolo Ronchi, Donatella Rescigno, Barbara Bertani, Anna Maria Capelli, Sara Guariento, Gessica Marchini, Marco Milioli, Nicola Cesari, Giuseppina Federico and 13 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Daniele PalaChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Paolo RonchiChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.ORCID https://orcid.org/0000-0001-5496-5068
Donatella RescignoAptuit, an Evotec Company, Via Alessandro Fleming 4, 37135 Verona, Italy.
Barbara BertaniAptuit, an Evotec Company, Via Alessandro Fleming 4, 37135 Verona, Italy.
Anna Maria CapelliChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Sara GuarientoChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Gessica MarchiniChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Marco MilioliChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Nicola CesariChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Giuseppina FedericoChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Andrea GrandiChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Franco F StellariChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Sergio Xanxo FernandezChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Alice PappaniChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Luca VenturiChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.ORCID https://orcid.org/0000-0003-4248-7761
Matteo BiagettiChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Maurizio CivelliChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Teresa SemeraroAptuit, an Evotec Company, Via Alessandro Fleming 4, 37135 Verona, Italy.
Federica BianchiAptuit, an Evotec Company, Via Alessandro Fleming 4, 37135 Verona, Italy.
Iuni M L TristAptuit, an Evotec Company, Via Alessandro Fleming 4, 37135 Verona, Italy.ORCID https://orcid.org/0000-0003-0944-5869
Rosaria RemelliAptuit, an Evotec Company, Via Alessandro Fleming 4, 37135 Verona, Italy.
Elisabetta ArmaniChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.ORCID https://orcid.org/0000-0002-2835-2652
Daniela PizziraniChiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ALK5 inhibitors represent an attractive therapeutic approach for the treatment of a variety of pathologies, including cancer and fibrosis. Herein, we report the design and

Identifiers

PMID39563792
PMCPMC11571009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.