Evidence map›Paper›PMID 39563743›Full record

ArticleWorld journal of gastroenterology2024

Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis.

Hong-Wei Sun, Yong-Yu Bai, Zhen-Liu Qin, Ri-Zhao Li, Tinotenda Blessing Madzikatire, Percy David Papa Akuetteh, Qiang Li, Hong-Ru Kong, Yue-Peng Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Wei SunNational Key Clinical Specialty (General Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Yong-Yu BaiNational Key Clinical Specialty (General Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Zhen-Liu QinWenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Ri-Zhao LiWenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Tinotenda Blessing MadzikatireWenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Percy David Papa AkuettehWenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Qiang LiNational Key Clinical Specialty (General Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Hong-Ru KongNational Key Clinical Specialty (General Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Yue-Peng JinNational Key Clinical Specialty (General Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. quiet1981@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP), the initially triggered inflammatory process in the pancreas, can be life-threatening. It has been reported that 15-lipoxygenase may promote the removal of damaged intracellular components, maintain intracellular homeostasis, and promote apoptosis by upregulating the activity of caspases. Despite an increased understanding of the lipoxygenase pathway in inflammation and immune diseases, the role of the

aimTo investigate the effect of

methodsModel rats were transfected with

resultsOur

conclusionOur findings demonstrate a regulatory role of

Indexed as

ApoptosisArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseCeruletideDisease Models, AnimalPancreasPancreatitisTransfectionAcute DiseaseAmylasesAnimalsCaspase 3HumansLentivirusMaleNF-kappa B12-15-lipoxygenaseAmylasesArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseCasp3 protein, ratCaspase 3CeruletideNF-kappa BRNA, Messenger12/15-lipoxygenaseAcute pancreatitisApoptosisAutophagyCerulein

Identifiers

PMID39563743
PMCPMC11572619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.