Evidence map›Paper›PMID 39563674›Full record

ArticleMolecular vision2024

Toll-like receptor-4 expression and oxidative stress in ocular rosacea.

Nilufer Yesilirmak, Neslihan Bukan, Busra Kurt, Tugba Fatsa, Sema Yuzbasıoglu, Min Zhao, Tugrul Hosbul, Jean-Louis Bourges, Francine Behar-Cohen

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In one paragraph

Article in Molecular vision, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nilufer YesilirmakCentre de Recherche des Cordeliers, INSERM, Université Paris Cité, Sorbonne Université, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.
Neslihan BukanDepartment of Medical Biochemistry, University of Gazi, Ankara, Turkey.
Busra KurtDepartment of Ophthalmology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.
Tugba FatsaMolecular Application and Research Unit of R and D Laboratory, University of Health Sciences, Etlik, Ankara, Turkey.
Sema YuzbasıogluDepartment of Ophthalmology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.
Min ZhaoCentre de Recherche des Cordeliers, INSERM, Université Paris Cité, Sorbonne Université, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.
Tugrul HosbulDepartment of Medical Microbiology, Gulhane Faculty of Medicine, University of Health Sciences, Etlik, Ankara, Turkey.
Jean-Louis BourgesCentre de Recherche des Cordeliers, INSERM, Université Paris Cité, Sorbonne Université, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.
Francine Behar-CohenCentre de Recherche des Cordeliers, INSERM, Université Paris Cité, Sorbonne Université, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate systemic and ocular toll-like receptor (TLR)-4 expression and its association with oxidative stress markers in ocular rosacea (OR). Methods: This prospective study included 40 patients with rosacea with ocular involvement and 20 healthy volunteers. Tear break-up time (TBUT), Schirmer test, meibomoscore, and ocular surface disease index (OSDI) scores were estimated for all participants. TLR-4 expression in conjunctival epithelium and peripheral blood mononuclear cells was quantified using real-time polymerase chain reaction (RT-PCR). In the tears and serum samples of all participants, antioxidant status (TAS), total oxidant status (TOS), and arylesterase (ARE) activation levels were measured using a fully automated spectrophotometric method, and the oxidative stress index (OSI) was calculated. Results: TLR-4 expression levels and oxidative stress status (TOS and OSI values) were significantly higher ( Conclusions: TLR-4 and oxidative stress both play important roles in OR pathophysiology and are closely related to clinical findings.

Indexed as

AntioxidantsOxidative StressRosaceaTearsToll-Like Receptor 4AdultAgedBiomarkersCarboxylic Ester HydrolasesCase-Control StudiesConjunctivaFemaleHumansLeukocytes, MononuclearMaleMiddle AgedAntioxidantsarylesteraseBiomarkersCarboxylic Ester HydrolasesTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID39563674
PMCPMC11575841

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.